靶向Trop2的免疫正电子发射断层显像配体
Trop2-targeted immunoPET ligands.
作者信息
Liang Steven H
机构信息
Department of Radiology and Imaging Sciences, Emory University Atlanta, Georgia 30322, United States.
出版信息
Am J Nucl Med Mol Imaging. 2025 Jun 25;15(3):105-108. doi: 10.62347/GHKA7738. eCollection 2025.
Abstract
Trop2 is overexpressed in various tumors and serves as a key biomarker. Targeted immunoPET ligands, mainly developed from Trop2 monoclonal antibodies and nanobodies, provide the landscape of heterogeneous expression of Trop2 in tumors, which has great potential in improving accuracy of cancer diagnosis and staging, as well as decision-making in therapy.
摘要
Trop2在多种肿瘤中过表达，是一种关键生物标志物。主要由Trop2单克隆抗体和纳米抗体开发而来的靶向免疫正电子发射断层显像（immunoPET）配体，展现了Trop2在肿瘤中异质性表达的情况，这在提高癌症诊断和分期的准确性以及治疗决策方面具有巨大潜力。
相似文献
1
Trop2-targeted immunoPET ligands.靶向Trop2的免疫正电子发射断层显像配体
Am J Nucl Med Mol Imaging. 2025 Jun 25;15(3):105-108. doi: 10.62347/GHKA7738. eCollection 2025.
2
ImmunoPET imaging of Trop2 expression in triple-negative breast cancer using [Cu]Cu-NOTA-Trodelvy-F(ab').使用[铜]Cu-NOTA-Trodelvy-F(ab')对三阴性乳腺癌中Trop2表达进行免疫正电子发射断层扫描成像
Eur J Nucl Med Mol Imaging. 2025 Feb 25. doi: 10.1007/s00259-025-07167-5.
3
TROP2-targeted molecular imaging: a promising tool for precision oncology.靶向TROP2的分子成像：精准肿瘤学的一种有前景的工具。
Am J Nucl Med Mol Imaging. 2025 Jun 25;15(3):109-123. doi: 10.62347/BKIS3836. eCollection 2025.
4
[Tc]Tc-MY6349 Probe for Trop2-Targeted SPECT Imaging: From Preclinical to Pilot Clinical Study.用于靶向Trop2的单光子发射计算机断层显像（SPECT）成像的锝[Tc]Tc-MY6349探针：从临床前研究到初步临床研究
J Nucl Med. 2025 Apr 1;66(4):543-551. doi: 10.2967/jnumed.124.268564.
5
[Zr]Zr-DFO-Trodelvy immunoPET for noninvasive Trop2 imaging in bladder cancer.[锆]锆-去铁胺-戈沙妥珠单抗免疫正电子发射断层扫描用于膀胱癌中Trop2的无创成像
Am J Nucl Med Mol Imaging. 2025 Jun 25;15(3):87-96. doi: 10.62347/KKEE6954. eCollection 2025.
6
Trophoblast cell-surface antigen 2 expression in lung cancer patients and the effects of anti-cancer treatments.肺癌患者滋养层细胞表面抗原 2 的表达及其抗癌治疗的影响。
J Cancer Res Clin Oncol. 2022 Sep;148(9):2455-2463. doi: 10.1007/s00432-021-03784-3. Epub 2021 Sep 17.
7
Evolution of TROP2: Biological insights and clinical applications.TROP2的演变：生物学见解与临床应用
Eur J Med Chem. 2025 Oct 15;296:117863. doi: 10.1016/j.ejmech.2025.117863. Epub 2025 Jun 13.
8
Assessment of TROP2, CEACAM5 and DLL3 in metastatic prostate cancer: Expression landscape and molecular correlates.转移性前列腺癌中TROP2、癌胚抗原相关细胞黏附分子5（CEACAM5）和Delta样蛋白3（DLL3）的评估：表达情况及分子关联
NPJ Precis Oncol. 2024 May 17;8(1):104. doi: 10.1038/s41698-024-00599-6.
9
ImmunoPET imaging of Trop2 expression in solid tumors with nanobody tracers.使用纳米抗体示踪剂对实体瘤中Trop2表达进行免疫正电子发射断层显像（ImmunoPET）成像。
Eur J Nucl Med Mol Imaging. 2024 Jan;51(2):380-394. doi: 10.1007/s00259-023-06454-3. Epub 2023 Oct 4.
10
ImmunoPET imaging of c-Met using a nanobody-based tracer [Ga]Ga-NOTA-PFCM01 in pancreatic ductal adenocarcinoma models and non-human primates.在胰腺导管腺癌模型和非人灵长类动物中，使用基于纳米抗体的示踪剂[镓]镓-诺他-全氟碳M01对c-Met进行免疫正电子发射断层显像。
Eur J Nucl Med Mol Imaging. 2025 Jul 9. doi: 10.1007/s00259-025-07441-6.
本文引用的文献
1
Immuno-PET/CT Imaging of Trop2 with [F]AlF-RESCA-T4 Differentiates Lung Cancer from Inflammation.使用[F]AlF-RESCA-T4对Trop2进行免疫正电子发射断层扫描/计算机断层扫描成像可区分肺癌与炎症。
J Nucl Med. 2024 Dec 3;65(12):1904-1910. doi: 10.2967/jnumed.124.268751.
2
68Ga-MY6349 PET/CT imaging to assess Trop2 expression in multiple types of cancer.68Ga-MY6349正电子发射断层显像/X线计算机体层成像（PET/CT）用于评估多种癌症中Trop2的表达情况。
J Clin Invest. 2024 Nov 7;135(1):e185408. doi: 10.1172/JCI185408.
3
ImmunoPET imaging of Trop2 in patients with solid tumours.免疫 PET 显像在实体瘤患者中的 Trop2 研究。
EMBO Mol Med. 2024 May;16(5):1143-1161. doi: 10.1038/s44321-024-00059-5. Epub 2024 Apr 2.
4
ImmunoPET imaging of Trop2 expression in solid tumors with nanobody tracers.使用纳米抗体示踪剂对实体瘤中Trop2表达进行免疫正电子发射断层显像（ImmunoPET）成像。
Eur J Nucl Med Mol Imaging. 2024 Jan;51(2):380-394. doi: 10.1007/s00259-023-06454-3. Epub 2023 Oct 4.
5
Radiochemistry for positron emission tomography.正电子发射断层成像中的放射性化学
Nat Commun. 2023 Jun 5;14(1):3257. doi: 10.1038/s41467-023-36377-4.
6
Advances in Trop2-targeted therapy: Novel agents and opportunities beyond breast cancer. Trop2 靶向治疗的进展：乳腺癌以外的新型药物和机会。
Pharmacol Ther. 2022 Nov;239:108296. doi: 10.1016/j.pharmthera.2022.108296. Epub 2022 Oct 5.
7
Theranostic application of Cu/Lu-labeled anti-Trop2 monoclonal antibody in pancreatic cancer tumor models.铜/镥标记抗 Trop2 单克隆抗体在胰腺癌肿瘤模型中的诊断与治疗应用。
Eur J Nucl Med Mol Imaging. 2022 Dec;50(1):168-183. doi: 10.1007/s00259-022-05954-y. Epub 2022 Sep 5.
8
Single-Domain Antibody Theranostics on the Horizon.单域抗体治疗学的前景。
J Nucl Med. 2022 Oct;63(10):1475-1479. doi: 10.2967/jnumed.122.263907. Epub 2022 Jul 14.
9
ImmunoPET of trophoblast cell-surface antigen 2 (Trop-2) expression in pancreatic cancer.免疫 PET 检测胰腺癌中滋养层细胞表面抗原 2（Trop-2）的表达。
Eur J Nucl Med Mol Imaging. 2022 Feb;49(3):861-870. doi: 10.1007/s00259-021-05563-1. Epub 2021 Sep 14.
10
Targeting Trop-2 in solid tumors: future prospects.靶向实体瘤中的Trop-2：未来前景
Onco Targets Ther. 2019 Mar 1;12:1781-1790. doi: 10.2147/OTT.S162447. eCollection 2019.
Zotero 插件