Dupont J, Ewens-Luby S, Mathias M M
Lipids. 1985 Nov;20(11):825-33. doi: 10.1007/BF02534408.
A review of research in the authors' laboratories regarding effects of dietary fat polyunsaturation upon longevity in rats and some aspects of the regulation of cholesterol metabolism with regard to age of rats and humans is presented. The longevity of the rat was found to be enhanced by consumption of dietary fat providing a polyunsaturated to saturated fatty acid (P/S) ratio of 0.3 to 1, corresponding to about 5-12% of energy (en%) as linoleate, compared with less or more polyunsaturated fat. Mechanisms of the effects of the fats upon cholesterol metabolism were studied. With advancing age, there seems to be a decline in the rate of catabolism of cholesterol, resulting in longer retention in the body of the rat. In the human, there seems to be a decline in regulation of uptake of cholesterol by leukocytes and, therefore, perhaps other tissues, resulting in increased synthesis of cholesterol by the peripheral tissues. Moderate rather than high dietary consumption of polyunsaturated fat seems to be favorable to metabolic processes contributing to longevity.
本文综述了作者实验室关于膳食脂肪多不饱和程度对大鼠寿命的影响以及大鼠和人类胆固醇代谢调节的某些方面与年龄关系的研究。与多不饱和脂肪含量较低或较高的情况相比，发现大鼠食用多不饱和脂肪酸与饱和脂肪酸（P/S）比例为0.3至1（相当于约5-12%的能量以亚油酸形式存在）的膳食脂肪时，其寿命会延长。研究了这些脂肪对胆固醇代谢的影响机制。随着年龄的增长，大鼠体内胆固醇的分解代谢速率似乎会下降，导致胆固醇在大鼠体内的保留时间延长。在人类中，白细胞以及可能其他组织对胆固醇摄取的调节似乎会下降，导致外周组织中胆固醇的合成增加。适度而非高量摄入多不饱和脂肪似乎有利于促进长寿的代谢过程。
