Rossini Michela, Fernandes Tânia, D'Arsiè Irene, Filadi Riccardo
Department of Biomedical Sciences, University of Padua, Padua, Italy.
Institute of Neuroscience, National Research Council (CNR), Padua, Italy.
Contact (Thousand Oaks). 2025 Jul 17;8:25152564251330069. doi: 10.1177/25152564251330069. eCollection 2025 Jan-Dec.
Alzheimer's disease (AD) is the most common neurodegenerative disorder of the elderly and no cure is currently available, as the mechanisms leading to neuronal damage and cognitive impairments remain elusive. In the last years, accumulating evidence highlighted early perturbations of the communication between mitochondria and endoplasmic reticulum (ER) in AD models. In this short review, we summarize recent findings linking alterations of ER-mitochondria coupling with typical AD hallmarks.
阿尔茨海默病（AD）是老年人中最常见的神经退行性疾病，目前尚无治愈方法，因为导致神经元损伤和认知障碍的机制仍不清楚。在过去几年中，越来越多的证据表明，AD模型中线粒体与内质网（ER）之间的通讯存在早期扰动。在这篇简短的综述中，我们总结了将内质网-线粒体偶联改变与典型AD特征联系起来的最新发现。
