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Static vs. cidal: it's not complex; it's simply incorrect.静态与杀菌：这并不复杂；只是不正确。
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引用本文的文献

1
Reply to Spellberg et al., "Static vs cidal: it's not complex; it's simply incorrect".对斯佩尔伯格等人《静态与杀菌：并非复杂，而是根本错误》一文的回应
Antimicrob Agents Chemother. 2025 Aug 6;69(8):e0061525. doi: 10.1128/aac.00615-25. Epub 2025 Jul 21.

本文引用的文献

1
Antibiotic killing of drug-induced bacteriostatic cells.抗生素对药物诱导的抑菌细胞的杀伤作用。
Antimicrob Agents Chemother. 2025 May 7;69(5):e0015625. doi: 10.1128/aac.00156-25. Epub 2025 Mar 26.
2
Bactericidal versus bacteriostatic antibacterials: clinical significance, differences and synergistic potential in clinical practice.杀菌性与抑菌性抗菌药物：临床意义、差异及临床实践中的协同潜力
J Antimicrob Chemother. 2025 Jan 3;80(1):1-17. doi: 10.1093/jac/dkae380.
3
Mortality and clinical cure rates for pneumonia: a systematic review, meta-analysis, and trial sequential analysis of randomized control trials comparing bactericidal and bacteriostatic antibiotic treatments.肺炎病死率和临床治愈率：比较杀菌和抑菌抗生素治疗的随机对照试验的系统评价、荟萃分析和试验序贯分析。
Clin Microbiol Infect. 2022 Jul;28(7):936-945. doi: 10.1016/j.cmi.2021.12.021. Epub 2022 Jan 14.
4
Oral Lefamulin vs Moxifloxacin for Early Clinical Response Among Adults With Community-Acquired Bacterial Pneumonia: The LEAP 2 Randomized Clinical Trial.口服来法莫林与莫西沙星治疗社区获得性细菌性肺炎成人患者的早期临床反应：LEAP 2随机临床试验
JAMA. 2019 Nov 5;322(17):1661-1671. doi: 10.1001/jama.2019.15468.
5
Omadacycline for Community-Acquired Bacterial Pneumonia.奥马环素治疗社区获得性细菌性肺炎。
N Engl J Med. 2019 Feb 7;380(6):517-527. doi: 10.1056/NEJMoa1800201.
6
Efficacy and Safety of Intravenous-to-oral Lefamulin, a Pleuromutilin Antibiotic, for the Treatment of Community-acquired Bacterial Pneumonia: The Phase III Lefamulin Evaluation Against Pneumonia (LEAP 1) Trial.截短侧耳素类抗生素静脉至口服给药的来法莫林治疗社区获得性细菌性肺炎的疗效和安全性：III期来法莫林抗肺炎评估（LEAP 1）试验
Clin Infect Dis. 2019 Nov 13;69(11):1856-1867. doi: 10.1093/cid/ciz090.
7
IGNITE4: Results of a Phase 3, Randomized, Multicenter, Prospective Trial of Eravacycline vs Meropenem in the Treatment of Complicated Intraabdominal Infections.IGNITE4 研究：依拉环素对比美罗培南治疗复杂性腹腔内感染的 3 期、随机、多中心、前瞻性试验结果。
Clin Infect Dis. 2019 Aug 30;69(6):921-929. doi: 10.1093/cid/ciy1029.
8
Busting the Myth of "Static vs Cidal": A Systemic Literature Review.打破“静态与杀菌”的神话：系统文献综述。
Clin Infect Dis. 2018 Apr 17;66(9):1470-1474. doi: 10.1093/cid/cix1127.
9
Randomized phase 2 trial to evaluate the clinical efficacy of two high-dosage tigecycline regimens versus imipenem-cilastatin for treatment of hospital-acquired pneumonia.随机 2 期临床试验评估两种高剂量替加环素方案与亚胺培南-西司他丁治疗医院获得性肺炎的临床疗效。
Antimicrob Agents Chemother. 2013 Apr;57(4):1756-62. doi: 10.1128/AAC.01232-12. Epub 2013 Jan 28.
10
Bactericidal and bacteriostatic action of chloramphenicol against memingeal pathogens.氯霉素对脑膜病原体的杀菌和抑菌作用。
Antimicrob Agents Chemother. 1979 Jul;16(1):13-18. doi: 10.1128/AAC.16.1.13.

Static vs. cidal: it's not complex; it's simply incorrect.

作者信息

Spellberg Brad, Wald-Dickler Noah, Holtom Paul, Meyer-Sautter Pascal, Camp Austin, Diaz Alejandro Diaz, Buhamad Ranya, Vazquez Ali Sebastian Meza, Aguirre-Garcia Gloria Mayela, Stanton Matthew, Butler-Wu Susan M, Chiu Isabelle, Ergenc Zeynep, Bhoojhawon Guru, Murri Rita, Maraolo Alberto Enrico, Cabanilla Gabriela, Riccardi Niccolò, Tshisevhe Vhudzani, Behenna Curtis, Williams Karen S, Kufel Wesley D, Wojciaczyk Natalia, Pimentel Bernardo Vidal, Muyidi Ahmed, Costa Rodrigo P L, Motta Fabrizio, Bortolussi-Courval Émilie, Lee Todd C, McDonald Emily, Ghanem Bassam, Nelson Zachary

机构信息

Los Angeles General Medical Center, Los Angeles, California, USA.

Department of Internal Medicine, Kantonsspital Glarus, Glarus, Switzerland.

出版信息

Antimicrob Agents Chemother. 2025 Aug 6;69(8):e0051325. doi: 10.1128/aac.00513-25. Epub 2025 Jul 21.

DOI:10.1128/aac.00513-25
PMID:40689788
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12326958/
Abstract
摘要