氯霉素对脑膜病原体的杀菌和抑菌作用。
Bactericidal and bacteriostatic action of chloramphenicol against memingeal pathogens.
作者信息
Rahal J J, Simberkoff M S
出版信息
Antimicrob Agents Chemother. 1979 Jul;16(1):13-18. doi: 10.1128/AAC.16.1.13.
Abstract
The bacteriostatic and bactericidal effects of chloramphenicol, ampicillin, tetracycline, and sulfisoxazole were compared against several potential meningeal pathogens. Chloramphenicol is bactericidal at clinically achievable concentrations against Haemophilus influenzae, Streptococcus pneumoniae, and Neisseria meningitidis. It is bacteriostatic against gram-negative bacilli of the family Enterobacteriaceae and against Staphylococcus aureus. Chloramphenicol has proven highly efficacious in the treatment of bacterial meningitis caused by those organisms against which it is bactericidal at low concentrations. Because leukocytic phagocytosis in the subarachnoid space is inefficient, we propose that bactericidal activity in cerebrospinal fluid is important for optimal therapy of bacterial meningitis. Chloramphenicol does not provide such activity in meningitis caused by enteric gram-negative bacilli.
摘要
比较了氯霉素、氨苄西林、四环素和磺胺异恶唑对几种潜在脑膜病原体的抑菌和杀菌作用。氯霉素在临床可达到的浓度下对流感嗜血杆菌、肺炎链球菌和脑膜炎奈瑟菌具有杀菌作用。它对肠杆菌科革兰氏阴性杆菌和金黄色葡萄球菌具有抑菌作用。氯霉素已被证明在治疗由低浓度时具有杀菌作用的那些病原体引起的细菌性脑膜炎方面非常有效。由于蛛网膜下腔中的白细胞吞噬作用效率低下，我们认为脑脊液中的杀菌活性对于细菌性脑膜炎的最佳治疗很重要。氯霉素在由肠道革兰氏阴性杆菌引起的脑膜炎中不具有这种活性。
相似文献
1
Bactericidal and bacteriostatic action of chloramphenicol against memingeal pathogens.氯霉素对脑膜病原体的杀菌和抑菌作用。
Antimicrob Agents Chemother. 1979 Jul;16(1):13-18. doi: 10.1128/AAC.16.1.13.
2
[Bactericidal action of chloramphenicol and synergism with beta-lactam antibiotics].[氯霉素的杀菌作用及与β-内酰胺类抗生素的协同作用]
Padiatr Padol. 1983;18(1):11-20.
3
Bacterial meningitis.细菌性脑膜炎
Ann N Y Acad Sci. 1967 Sep 27;145(2):488-98. doi: 10.1111/j.1749-6632.1967.tb50249.x.
4
Antibiotic concentrations in liquor compared to the minimal inhibitory concentrations of isolates in paediatric bacterial meningitis. The Finnish Study Group.
Chemotherapy. 1991;37(1):1-5. doi: 10.1159/000238825.
5
Antimicrobial susceptibility of cerebrospinal isolates from patients with meningitis.脑膜炎患者脑脊液分离株的抗菌药敏性。
Neuro Endocrinol Lett. 2007 Nov;28 Suppl 3:5-6.
6
The penetration of broad-spectrum antibiotics into the cerebrospinal fluid.广谱抗生素在脑脊液中的渗透情况。
Ann N Y Acad Sci. 1967 Sep 27;145(2):473-81. doi: 10.1111/j.1749-6632.1967.tb50247.x.
7
[Can chloramphenicol be combined with beta-lactam antibiotics? (author's transl)].
Infection. 1980;8 Suppl 3:S 234-8.
8
Potential of the fluoroketolide RBx 14255 against Streptococcus pneumoniae, Neisseria meningitidis and Haemophilus influenzae in an experimental murine meningitis model.氟喹诺酮酮 RBx 14255 对实验性鼠脑膜炎模型中肺炎链球菌、脑膜炎奈瑟菌和流感嗜血杆菌的作用。
J Antimicrob Chemother. 2019 Jul 1;74(7):1962-1970. doi: 10.1093/jac/dkz119.
9
[Cephalothin in the antibiogram].[抗菌谱中的头孢噻吩]
Arzneimittelforschung. 1967 Dec;17(12):1537-41.
10
Effect of ampicillin and chloramphenicol against Streptococcus pneumoniae and Neisseria meningitidis.氨苄西林和氯霉素对肺炎链球菌和脑膜炎奈瑟菌的作用。
Antimicrob Agents Chemother. 1979 Feb;15(2):240-42. doi: 10.1128/AAC.15.2.240.
引用本文的文献
1
Static vs. cidal: it's not complex; it's simply incorrect.静态与杀菌：这并不复杂；只是不正确。
Antimicrob Agents Chemother. 2025 Aug 6;69(8):e0051325. doi: 10.1128/aac.00513-25. Epub 2025 Jul 21.
2
Antibacterial properties of silver and gold nanoparticles synthesized using Cannabis sativa waste extract against Pseudomonas aeruginosa.利用大麻废弃物提取物合成的银和金纳米颗粒对铜绿假单胞菌的抗菌特性
J Cannabis Res. 2025 Apr 12;7(1):20. doi: 10.1186/s42238-025-00272-0.
3
Bactericidal versus bacteriostatic antibacterials: clinical significance, differences and synergistic potential in clinical practice.杀菌性与抑菌性抗菌药物：临床意义、差异及临床实践中的协同潜力
J Antimicrob Chemother. 2025 Jan 3;80(1):1-17. doi: 10.1093/jac/dkae380.
4
produces (p)ppGpp in response to the bacteriostatic antibiotic chloramphenicol to prevent its potential bactericidal effect.在受到抑菌抗生素氯霉素刺激时产生（p）ppGpp，以防止其潜在的杀菌作用。
mLife. 2022 Jun 30;1(2):101-113. doi: 10.1002/mlf2.12031. eCollection 2022 Jun.
5
Bimetallic nanoparticle production using and waste extracts.使用[具体物质]和[具体物质]废料提取物生产双金属纳米颗粒。 （你原文中“using”后面应该缺失了相关内容）
RSC Adv. 2024 Feb 9;14(8):5309-5318. doi: 10.1039/d3ra07134k. eCollection 2024 Feb 7.
6
Optimizing tylosin dosage for co-infection of and in pigs using pharmacokinetic/pharmacodynamic modeling.使用药代动力学/药效学模型优化泰乐菌素在猪感染[未提及的两种病原体]混合感染时的剂量。
Front Pharmacol. 2023 Sep 22;14:1258403. doi: 10.3389/fphar.2023.1258403. eCollection 2023.
7
The Pioneer platform: A novel approach for selection of selective anti-cancer cytotoxic activity in bacteria through co-culturing with engineered human cells.先锋平台：通过与工程化人类细胞共培养选择具有选择性抗癌细胞毒性的新型细菌方法。
PLoS One. 2023 Jun 6;18(6):e0286741. doi: 10.1371/journal.pone.0286741. eCollection 2023.
8
Hydrocinnamic Acid and Perillyl Alcohol Potentiate the Action of Antibiotics against .氢化肉桂酸和紫苏醇增强抗生素对……的作用 。
你提供的原文似乎不完整，“against”后面缺少具体内容。
Antibiotics (Basel). 2023 Feb 9;12(2):360. doi: 10.3390/antibiotics12020360.
9
Trend of Changes in Chloramphenicol Resistance during the Years 2017-2020: A Retrospective Report from Israel.2017 - 2020年期间氯霉素耐药性变化趋势：以色列的一份回顾性报告。
Antibiotics (Basel). 2023 Jan 18;12(2):196. doi: 10.3390/antibiotics12020196.
10
Sepsis Management in Southeast Asia: A Review and Clinical Experience.东南亚地区的脓毒症管理：综述与临床经验
J Clin Med. 2022 Jun 23;11(13):3635. doi: 10.3390/jcm11133635.
本文引用的文献
1
COMPARISON OF THE ACTION OF STREPTOMYCIN, POLYMYXIN B, AUREOMYCIN AND CHLOROMYCETIN ON H. PERTUSSIS, H. PARAPERTUSSIS, H. INFLUENZAE AND FIVE ENTERIC STRAINS OF GRAM-NEGATIVE BACILLI.链霉素、多粘菌素B、金霉素和氯霉素对百日咳杆菌、副百日咳杆菌、流感嗜血杆菌及五种肠道革兰氏阴性杆菌菌株作用的比较
J Clin Invest. 1949 Sep;28(5 Pt 1):867-70. doi: 10.1172/JCI102170.
2
3
Cerebrospinal fluid immunoglobulins in bacterial meningitis. A possible role for antibody in pneumococcal meningitis.细菌性脑膜炎中的脑脊液免疫球蛋白。抗体在肺炎球菌性脑膜炎中的可能作用。
Arch Neurol. 1971 Sep;25(3):218-24. doi: 10.1001/archneur.1971.00490030044004.
4
Phagocytosis (third of three parts).吞噬作用（三部分中的第三部分）。
N Engl J Med. 1974 Apr 11;290(15):833-9. doi: 10.1056/NEJM197404112901506.
5
Treatment of gram-negative bacillary meningitis in adults.成人革兰氏阴性杆菌脑膜炎的治疗
Ann Intern Med. 1972 Aug;77(2):295-302. doi: 10.7326/0003-4819-77-2-295.
6
Gram-negative bacillary meningitis.革兰氏阴性杆菌性脑膜炎
Am J Med. 1975 Dec;59(6):829-36. doi: 10.1016/0002-9343(75)90468-4.
7
Susceptibility of Haemophilus influenzae type b to cefatrizine, ampicillin, and chloramphenicol.b型流感嗜血杆菌对头孢曲嗪、氨苄西林和氯霉素的敏感性。
Antimicrob Agents Chemother. 1976 Aug;10(2):322-4. doi: 10.1128/AAC.10.2.322.
8
Cerebrospinal fluid immunoglobulins and complement in meningococcal meningitis.脑脊液免疫球蛋白和补体在脑膜炎球菌性脑膜炎中的情况
J Clin Pathol. 1977 Aug;30(8):720-2. doi: 10.1136/jcp.30.8.720.
9
Quantitative relationships of the fourth complement component in human cerebrospinal fluid.人脑脊液中第四补体成分的定量关系
J Lab Clin Med. 1977 Mar;89(3):615-21.
10
Effect of ampicillin and chloramphenicol against Haemophilus influenzae.氨苄青霉素和氯霉素对流感嗜血杆菌的作用。
Pediatrics. 1978 Mar;61(3):406-9. doi: 10.1542/peds.61.3.406.
Zotero 插件