丘脑网状核中的小白蛋白和生长抑素神经元调节小鼠初级视觉皮层（V1）中的视觉信息处理。
Parvalbumin and Somatostatin Neurons in the Thalamic Reticular Nucleus Modulate Visual Information Processing in V1 of Mouse.
作者信息
Bu Jiamin, Xu Guangwei, Zhou Yifeng
机构信息
Hefei National Laboratory for Physical Science at the Microscale, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, 230026, China.
State Key Laboratory of Brain and Cognitive Science, Institute of Psychology, Chinese Academy of Science, Hefei, 230026, China.
出版信息
Neurosci Bull. 2025 Jul 21. doi: 10.1007/s12264-025-01458-5.
The thalamic reticular nucleus (TRN) plays a crucial role in regulating sensory encoding, even at the earliest stages of visual processing, as evidenced by numerous studies. Orientation selectivity, a vital neural response, is essential for detecting objects through edge perception. Here, we demonstrate that somatostatin (SOM)-expressing and parvalbumin (PV)-expressing neurons in the TRN project to the dorsal lateral geniculate nucleus and modulate orientation selectivity and the capacity for visual information processing in the primary visual cortex (V1). These findings show that SOM-positive and PV-positive neurons in the TRN are powerful modulators of visual information encoding in V1, revealing a novel role for this thalamic nucleus in influencing visual processing.
丘脑网状核（TRN）在调节感觉编码中起着关键作用，即使在视觉处理的最早阶段也是如此，大量研究证明了这一点。方向选择性是一种重要的神经反应，对于通过边缘感知检测物体至关重要。在这里，我们证明，TRN中表达生长抑素（SOM）和表达小白蛋白（PV）的神经元投射到背外侧膝状核，并调节初级视觉皮层（V1）中的方向选择性和视觉信息处理能力。这些发现表明，TRN中SOM阳性和PV阳性神经元是V1中视觉信息编码的强大调节因子，揭示了这个丘脑核在影响视觉处理方面的新作用。
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