Zhang Yue, Liu Xinyu, Zhang Zhongze, Sun Weiyan, Yue Wenjing, Liu Le, Zhu Yi, Zhang Xu, Wang Hong
Tianjin Key Laboratory of Metabolic Diseases, The Province and Ministry Co-Sponsored Collaborative Innovation Center for Medical Epigenetics, Center for Cardiovascular Diseases, Research Center of Basic Medical Sciences, Department of Physiology and Pathophysiology, Tianjin Medical University, Tianjin, China.
Division of Cardiology, Department of Internal Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology and Hubei Key Laboratory of Genetics and Molecular Mechanisms of Cardiological Disorder, Wuhan, Hubei, China.
J Cardiovasc Transl Res. 2025 Jul 21. doi: 10.1007/s12265-025-10652-9.
Hypertrophic cardiomyopathy (HCM) is one of the most prevalent hereditary cardiovascular diseases. Eicosanoids are known to play a significant role in cardiovascular diseases and serve as biomarkers. In this study, plasma eicosanoids were profiled by LC-MS in a cohort of 78 healthy individuals and 73 patients diagnosed with HCM. Our findings reveal HCM patients exhibit downregulation of various eicosanoids, including AA, 5,6-DHET, 12-HETE, LXA4, EPA, etc. Notably, the combined predictive model incorporating 12-HETE and EPA demonstrates significant diagnostic value for HCM. Additionally, ten closely related metabolites showed significant positive correlations within the metabolic network graph. Eicosanoids such as 17,18-EEQ, LXA4, and 13-oxo-ODE exhibit significant negative correlations with plasma concentrations of hs-CRP and NT-proBNP in patients. Alterations in eicosanoid metabolism may be implicated in the pathophysiological processes underlying HCM.
肥厚型心肌病（HCM）是最常见的遗传性心血管疾病之一。类二十烷酸在心血管疾病中发挥重要作用，并作为生物标志物。在本研究中，通过液相色谱-质谱联用（LC-MS）对78名健康个体和73名诊断为HCM的患者的血浆类二十烷酸进行了分析。我们的研究结果显示，HCM患者表现出多种类二十烷酸的下调，包括花生四烯酸（AA）、5,6-二羟基二十碳四烯酸（5,6-DHET）、12-羟基二十碳四烯酸（12-HETE）、白三烯A4（LXA4）、二十碳五烯酸（EPA）等。值得注意的是，包含12-HETE和EPA的联合预测模型对HCM具有显著的诊断价值。此外，在代谢网络图中，十种密切相关的代谢物显示出显著的正相关。17,18-二羟基二十碳三烯酸（17,18-EEQ）、LXA4和13-氧代-十八碳二烯酸（13-oxo-ODE）等类二十烷酸与患者血浆中高敏C反应蛋白（hs-CRP）和N末端脑钠肽前体（NT-proBNP）的浓度呈显著负相关。类二十烷酸代谢的改变可能与HCM的病理生理过程有关。
