Zhou Xiaoying, Wang Dan, Cao Shouming, Tu Yi, Chen Rui, Huang Haosu, Lou Wenrong
Department of Otolaryngology-Head and Neck Surgery, The Second Affiliated Hospital of Kunming Medical University, Kunming, People's Republic of China.
Department of Algology, The Second Affiliated Hospital of Kunming Medical University, Kunming, People's Republic of China.
J Inflamm Res. 2025 Jul 16;18:9401-9411. doi: 10.2147/JIR.S533652. eCollection 2025.
Rheumatoid arthritis (RA) may share pathophysiological mechanisms with chronic rhinosinusitis (CRS), but its impact on CRS remains unclear. This study aimed to investigate the associations between RA and CRS disease severity, as well as postoperative recurrence risk.
A retrospective analysis was conducted on CRS patients who underwent functional endoscopic sinus surgery. Patients were divided into subgroups based on the presence of RA and gender. CRS patients were followed up for three years and categorized into non-recurrent and recurrent groups. Binary logistic regression analyses were performed to investigate the impact of RA on the risk of postoperative recurrence in CRS.
Among 568 CRS patients, 169 experienced recurrence after three years. The RA group showed a significantly higher recurrence rate than the non-RA group in both genders (P < 0.05). In addition, RA patients had younger age, higher body mass index, higher prevalence of nasal polyps, and higher baseline VAS, Lund-Kennedy, and Lund-Mackay scores. At three-year follow-up, the RA group demonstrated greater improvements in VAS and Lund-Kennedy scores (P < 0.05). Logistic regression identified RA, allergic rhinitis, and asthma as independent risk factors for CRS recurrence (P < 0.05). Unadjusted and adjusted analysis highlighted RA as an independent predictor in males and females. Kaplan-Meier analysis further revealed that RA was associated with a significantly higher risk of postoperative CRS recurrence (P < 0.05).
RA might aggravate the disease severity and affect the prognosis of CRS. Additionally, RA may be a potential risk factor for postoperative recurrence of CRS, regardless of gender.
类风湿性关节炎（RA）可能与慢性鼻-鼻窦炎（CRS）具有共同的病理生理机制，但其对CRS的影响尚不清楚。本研究旨在探讨RA与CRS疾病严重程度以及术后复发风险之间的关联。
对接受功能性鼻内镜鼻窦手术的CRS患者进行回顾性分析。根据是否存在RA和性别将患者分为亚组。对CRS患者进行三年随访，并分为未复发组和复发组。进行二元逻辑回归分析以研究RA对CRS术后复发风险的影响。
在568例CRS患者中，169例在三年后出现复发。RA组在男女两性中的复发率均显著高于非RA组（P < 0.05）。此外，RA患者年龄更小、体重指数更高、鼻息肉患病率更高，且基线视觉模拟评分（VAS）、Lund-Kennedy评分和Lund-Mackay评分更高。在三年随访时，RA组在VAS和Lund-Kennedy评分方面改善更大（P < 0.05）。逻辑回归确定RA、变应性鼻炎和哮喘为CRS复发的独立危险因素（P < 0.05）。未调整和调整分析均强调RA是男性和女性的独立预测因素。Kaplan-Meier分析进一步显示，RA与术后CRS复发风险显著更高相关（P < 0.05）。
RA可能会加重CRS的疾病严重程度并影响其预后。此外，无论性别如何，RA可能是CRS术后复发的潜在危险因素。
