Fokkens W J, Sedaghat A R, Soyka M B, Reitsma S
Department of Otorhinolarynogology and head/neck surgery, Amsterdam University Medical Centres, Amsterdam, The Netherlands.
Department of Otolaryngology - Head and Neck Surgery, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
Rhinology. 2024 Dec 1;62(6):652-658. doi: 10.4193/Rhin24.801.
This review discusses major developments in chronic rhinosinusitis. The latest papers on prevalence of the disease, the burden for patients and society, the lack of awareness, the development of patient classifications and the consequences for the management of the disease. Our discussion includes major developments in the treatment of the disease with biologics but also their limitations. Recent developments also include evolution in the goals of care, where until recently we were content with control of disease but now start to aim for remission and maybe even cure. To reach that aim we need better definitions of disease, outcomes and biomarkers to predict the optimal moment of intervention in the development of the disease. Time will tell whether earlier intervention can prevent development of the disease and later sequelae.
本综述讨论了慢性鼻-鼻窦炎的主要进展。关于该疾病的患病率、对患者和社会的负担、认识不足、患者分类的发展以及对疾病管理的影响的最新论文。我们的讨论包括使用生物制剂治疗该疾病的主要进展及其局限性。近期进展还包括治疗目标的演变，直到最近我们满足于疾病的控制，但现在开始追求缓解甚至治愈。为实现这一目标，我们需要对疾病、结局和生物标志物进行更好的定义，以预测疾病发展过程中最佳干预时机。时间将证明早期干预是否能预防疾病的发展及其后期后遗症。
