Yakout Abdelrahman, Fluxa Daniela, Nassar Aziza, Gomez Victoria
Division of Gastroenterology and Hepatology, Mayo Clinic, Jacksonville, FL.
Department of Laboratory Medicine and Pathology, Mayo Clinic, Jacksonville, FL.
ACG Case Rep J. 2025 Jul 21;12(7):e01773. doi: 10.14309/crj.0000000000001773. eCollection 2025 Jul.
Autoimmune pancreatitis (AIP) and pancreatic cancer share clinical and radiological features, making biopsy the only definitive way of differentiating them. Numerous reports in the literature describe the co-occurrence of AIP and pancreatic cancer either in a synchronous manner or metachronous manner raising the question of which condition predisposes to the other and whether a causal relationship exists between them. Studies suggest shared mechanisms, including K-ras mutations and tumor suppressor gene silencing. This case highlights the importance of long-term surveillance in AIP patients to monitor for malignancy.
自身免疫性胰腺炎（AIP）与胰腺癌具有共同的临床和放射学特征，这使得活检成为鉴别二者的唯一确切方法。文献中有大量报告描述了AIP与胰腺癌以同时或异时的方式共同出现，这就引发了一个问题，即哪种疾病易诱发另一种疾病，以及它们之间是否存在因果关系。研究表明存在共同机制，包括K-ras突变和肿瘤抑制基因沉默。本病例强调了对AIP患者进行长期监测以筛查恶性肿瘤的重要性。
