Macinga Peter, Bajer Lukas, Del Chiaro Marco, Chari Suresh T, Dite Petr, Frulloni Luca, Ikeura Tsukasa, Kamisawa Terumi, Kubota Kensuke, Naitoh Itaru, Okazaki Kazuichi, Pezzilli Raffaele, Vujasinovic Miroslav, Spicak Julius, Hucl Tomas, Lӧhr Matthias
Department of Gastroenterology and Hepatology, Institute for Clinical and Experimental Medicine, Prague, Czech Republic.
Department of Surgery, University of Colorado Anschutz Medical Campus, Aurora, CO, 80045, USA.
Pancreatology. 2021 Aug;21(5):928-937. doi: 10.1016/j.pan.2021.03.007. Epub 2021 Mar 18.
Chronic pancreatitis is a known risk factor of pancreatic cancer (PDAC). A similar association has been suggested but not demonstrated for autoimmune pancreatitis (AIP).
The aim of our study was to identify and analyse all published cases of AIP and PDAC co-occurrence, focusing on the interval between the diagnoses and the cancer site within the pancreas.
Relevant studies were identified through automatic searches of the MEDLINE, EMBASE, Scopus, and Web of Science databases, and supplemented by manual checks of reference lists in all retrieved articles. Missing/unpublished data were obtained from the authors of relevant publications in the form of pre-prepared questionnaires.
A total of 45 cases of PDAC in AIP patients were identified, of which 12 were excluded from the analysis due to suspicions of duplicity or lack of sufficient data. Thirty-one patients (94%) had type 1 AIP. Synchronous occurrence of PDAC and AIP was reported in 11 patients (33%), metachronous in 22 patients (67%). In the metachronous group, the median period between diagnoses was 66.5 months (2-186) and a majority of cancers (86%) occurred more than two years after AIP diagnosis. In most patients (70%), the cancer originated in the part of the pancreas affected by AIP.
In the literature, there are reports on numerous cases of PDAC in AIP patients. PDAC is more frequent in AIP type 1 patients, typically metachronous in character, and generally found in the part of the pancreas affected by AIP.
慢性胰腺炎是胰腺癌（PDAC）的已知危险因素。对于自身免疫性胰腺炎（AIP），也有人提出过类似关联，但尚未得到证实。
我们研究的目的是识别和分析所有已发表的AIP与PDAC同时发生的病例，重点关注诊断间隔和胰腺内的癌症部位。
通过自动检索MEDLINE、EMBASE、Scopus和Web of Science数据库来识别相关研究，并通过人工检查所有检索文章中的参考文献列表进行补充。缺失/未发表的数据通过预先准备好的问卷形式从相关出版物的作者处获取。
共识别出45例AIP患者合并PDAC的病例，其中12例因疑似重复或数据不足而被排除在分析之外。31例患者（94%）为1型AIP。11例患者（33%）报告PDAC与AIP同时发生，22例患者（67%）为异时发生。在异时发生组中，诊断之间的中位时间为66.5个月（2 - 186个月），大多数癌症（86%）在AIP诊断后两年以上发生。在大多数患者（70%）中，癌症起源于受AIP影响的胰腺部分。
在文献中，有关于AIP患者中大量PDAC病例的报道。PDAC在1型AIP患者中更常见，通常为异时发生，并且一般发生在受AIP影响的胰腺部分。
