Shabi Yahya, Algarni Abdullah, Al Bshabshe Ali, Alazraqi Tarik, Patriquin Glenn, Bawazeer Abdulah Os, Mohammed Safia Abdullah, Habbash Sara, Somily Ali, Alqahtani Abdulah J, Alhamhhum Saeed M S
Department of Microbiology and Clinical Parasitology, College of Medicine, King Khalid University, Abha, Saudi Arabia.
Department of Family Medicine, Aseer Central Hospital, Abha, Saudi Arabia.
Front Microbiol. 2025 Jul 7;16:1617522. doi: 10.3389/fmicb.2025.1617522. eCollection 2025.
(PA) is a significant cause of nosocomial infections, and increasing antimicrobial resistance complicates management.
To characterize antimicrobial susceptibility trends, we conducted a retrospective study of PA clinical isolates over 10 years (2013-2022) at a tertiary care hospital in Saudi Arabia.
A total of 2,490 PA isolates were analyzed (1,452 from general wards and 1,038 from ICUs). Carbapenem resistance was observed in 40% of isolates; 37.5% were multidrug-resistant (MDR), 5.3% were extensively drug-resistant (XDR), and 3.5% met the criteria for difficult-to-treat resistance (DTR).
This study provides an overview of PA resistance pattern trends in Saudi Arabia and emphasizes the importance of establishing an antimicrobial stewardship program.
肺炎克雷伯菌是医院感染的重要原因，抗菌药物耐药性增加使管理变得复杂。
为了描述抗菌药物敏感性趋势，我们对沙特阿拉伯一家三级医院10年（2013 - 2022年）期间的肺炎克雷伯菌临床分离株进行了一项回顾性研究。
共分析了2490株肺炎克雷伯菌分离株（1452株来自普通病房，1038株来自重症监护病房）。40%的分离株观察到对碳青霉烯类耐药；37.5%为多重耐药（MDR），5.3%为广泛耐药（XDR），3.5%符合难治性耐药（DTR）标准。
本研究概述了沙特阿拉伯肺炎克雷伯菌耐药模式趋势，并强调了建立抗菌药物管理计划的重要性。
