Aldawsari Anbar, Tawfik Kamilia, Al-Zaagi Ibrahim
Pharmaceutical Services, King Saud Medical City, Riyadh, SAU.
Pharmacy, Riyadh Elm University, Riyadh, SAU.
Cureus. 2020 Dec 15;12(12):e12098. doi: 10.7759/cureus.12098.
Purpose The purpose of the study was to assess the bacterial resistance and annual antibiotic consumption at a tertiary care hospital in Riyadh, Saudi Arabia over a two-year period. Methods This retrospective cohort study was conducted at a tertiary care hospital in Riyadh, Saudi Arabia from January 1, 2016, to December 31, 2017. Results The results showed that there was no significant difference between 2016 and 2017 data regarding patient characteristics like bed occupancy rate, the average length of stay, and the number of admissions; the same was true for bacterial characteristics like the number of bacteria, percentage of isolates in the group, and multidrug resistance (MDR) percentage (p: >0.05). Between 2016 and 2017, there was a slight reduction in the sensitivity of () carbapenem-resistant Enterobacteriaceae (CRE) (97%, 86%) and () CRE (80%, 76%) towards colistin. There was also a decrease in the sensitivity of () multidrug-resistant organism (MDRO) from 42% to 29% against tigecycline, but an increase in the sensitivity of CRE (33%, 50%) and CRE (76%, 82%). The percentage of MDR strains in gram-positive bacteria showed that more than half of () were methicillin-resistant (61%, 59%) in 2016 and 2017 respectively. There was a reduction in the percentage of MDR strains in some gram-negative bacteria like () MDRO (24%, 19%), extended-spectrum beta-lactamases (ESBL) (56%, 50%), CRE (4%, 1%), CRE (49%, 33%), CRE (90%, 76%), and ( ESBL (54%, 50%). Conclusion MDRO bacteria are very common in the hospital where the study was conducted. Immediate action is required to tackle this problem.
目的 本研究旨在评估沙特阿拉伯利雅得一家三级医疗医院在两年期间的细菌耐药性和年度抗生素消耗量。方法 这项回顾性队列研究于2016年1月1日至2017年12月31日在沙特阿拉伯利雅得的一家三级医疗医院进行。结果 结果显示，2016年和2017年的数据在患者特征（如床位占用率、平均住院时间和入院人数）方面没有显著差异；细菌特征（如细菌数量、组内分离株百分比和多重耐药（MDR）百分比）也是如此（p：>0.05）。2016年至2017年期间，耐碳青霉烯类肠杆菌科细菌（CRE）（97%，86%）和CRE（80%，76%）对黏菌素的敏感性略有降低。多重耐药菌（MDRO）对替加环素的敏感性也从42%降至29%，但CRE（33%，50%）和CRE（76%，82%）的敏感性有所增加。革兰氏阳性菌中MDR菌株的百分比显示，2016年和2017年分别有超过一半的（）对甲氧西林耐药（61%，59%）。一些革兰氏阴性菌中MDR菌株的百分比有所降低，如MDRO（24%，19%）、超广谱β-内酰胺酶（ESBL）（56%，50%）、CRE（4%，1%）、CRE（49%，33%）、CRE（90%，76%）和ESBL（54%，50%）。结论 在进行研究的医院中，MDRO细菌非常常见。需要立即采取行动解决这个问题。
