在普通成年人群中，膳食槲皮素摄入量与代谢功能障碍相关脂肪性肝病的风险无关。

Dietary quercetin intake is not associated with risk of metabolic dysfunction-associated steatotic liver disease in a general adult population.

作者信息

Liu Juanjuan, Wu Hongmei, Gu Yeqing, Meng Ge, Wu Xuehui, Zhu Dandan, Zhang Qing, Liu Li, Lai Sizhen, Chen Yinxiao, Wang Dongli, Sun Shaomei, Wang Xing, Jia Qiyu, Song Kun, Niu Kaijun

机构信息

School of Public Health, Tianjin University of Traditional Chinese Medicine, 10 Poyanghu Road, West Area, Tuanbo New Town, Jinghai District, Tianjin, 301617, China.

School of Integrative Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, China.

出版信息

Eur J Nutr. 2025 Jul 22;64(5):246. doi: 10.1007/s00394-025-03764-0.

DOI:10.1007/s00394-025-03764-0

PMID:40694145

Abstract

BACKGROUND

Metabolic dysfunction associated steatotic liver disease (MASLD) is the most common liver disease threatening public health. Quercetin is considered a promising candidate for treating and preventing MASLD, due to its antioxidant and anti-inflammatory properties. However, few studies have evaluated the association of daily quercetin intake with the risk of MASLD in the general population.

METHODS

This prospective cohort study included 16,746 adults. Dietary quercetin intake was assessed using a validated food frequency questionnaire. Incident MASLD cases were ascertained annually by liver ultrasound and cardiometabolic risk factors. Multivariable Cox proportional-hazards models were used to evaluate the association between quercetin intake and the risk of MASLD.

RESULTS

The data from 16,746 participants, with an average follow-up time of approximately 3.47 years, were analyzed and 3,544 participants developed MASLD during follow-up. After Multivariable adjustment, the hazard ratio (95% confidence interval) for MASLD across increasing quartiles of quercetin intake was 1.00 (reference), 0.93 (0.85, 1.03), 1.01 (0.91, 1.12), and 1.04 (0.92, 1.17) (P for trend = 0.35). Similarly, the adjusted hazard ratio (95% confidence interval) for MASLD across increasing quartiles of energy density and per-unit-kilogram-body-weight intake was 1.00 (reference), 0.99 (0.89, 1.09), 0.98 (0.89, 1.09), 1.02 (0.92, 1.13) (P for trend = 0.77), and 1.00 (reference), 0.92 (0.84, 1.01), 0.92 (0.83, 1.02), 0.94 (0.83, 1.06) (P for trend = 0.29), respectively.

CONCLUSION

No association was observed between dietary quercetin intake and the incidence of MASLD. The findings of this study need to be confirmed in other populations.

摘要

背景

代谢功能障碍相关脂肪性肝病（MASLD）是威胁公众健康的最常见肝脏疾病。槲皮素因其抗氧化和抗炎特性，被认为是治疗和预防MASLD的有潜力的候选物质。然而，很少有研究评估普通人群中槲皮素每日摄入量与MASLD风险之间的关联。

方法

这项前瞻性队列研究纳入了16746名成年人。使用经过验证的食物频率问卷评估膳食槲皮素摄入量。每年通过肝脏超声和心脏代谢危险因素确定新发MASLD病例。采用多变量Cox比例风险模型评估槲皮素摄入量与MASLD风险之间的关联。

结果

分析了16746名参与者的数据，平均随访时间约为3.47年，3544名参与者在随访期间发生了MASLD。多变量调整后，随着槲皮素摄入量四分位数增加，MASLD的风险比（95%置信区间）分别为1.00（参考值）、0.93（0.85，1.03）、1.01（0.91，1.12）和1.04（0.92，1.17）（趋势P值=0.35）。同样，随着能量密度和每千克体重摄入量四分位数增加，MASLD的调整后风险比（95%置信区间）分别为1.00（参考值）、0.99（0.89，1.09）、0.98（0.89，1.09）、1.02（0.92，1.13）（趋势P值=0.77），以及1.00（参考值）、0.92（0.84，1.01）、0.92（0.83，1.02）、0.94（0.83，1.06）（趋势P值=0.29）。