Science Circle of the Department of Inorganic Chemistry, Medical University of Lublin, Dr. Witolda Chodźki 4a, 20-093 Lublin, Poland.
Department of Inorganic Chemistry, Medical University of Lublin, Dr. Witolda Chodźki 4a, 20-093 Lublin, Poland.
Molecules. 2024 Nov 6;29(22):5245. doi: 10.3390/molecules29225245.
Metabolic dysfunction-associated steatotic liver disease (MASLD) represents a chronic liver disease. The development of MASLD is influenced by a multitude of diseases associated with modern lifestyles, including but not limited to diabetes mellitus, hypertension, hyperlipidaemia and obesity. These conditions are often consequences of the adoption of unhealthy habits, namely a sedentary lifestyle, a lack of physical activity, poor dietary choices and excessive alcohol consumption. The treatment of MASLD is primarily based on modifying the patient's lifestyle and pharmacological intervention. Despite the absence of FDA-approved pharmacological agents for the treatment of MASLD, several potential therapeutic modalities have demonstrated efficacy in reversing the histopathological features of the disease. Among the botanical ingredients belonging to the flavonoid group is quercetin (QE). QE has been demonstrated to possess a number of beneficial physiological effects, including anti-inflammatory, anticancer and antifungal properties. Additionally, it functions as a natural antioxidant. Preclinical evidence indicates that QE may play a beneficial role in reducing liver damage and improving metabolic health. Early human studies also suggest that QE may be an effective treatment for MASLD due to its antioxidant, anti-inflammatory, and lipid-regulating properties. This review aims to summarize the available information on the therapeutic effects of QE in MASLD.
代谢相关脂肪性肝病（MASLD）是一种慢性肝病。MASLD 的发展受到多种与现代生活方式相关疾病的影响，包括但不限于糖尿病、高血压、高脂血症和肥胖症。这些疾病通常是不健康习惯的结果，例如久坐不动的生活方式、缺乏体育活动、不良的饮食选择和过量饮酒。MASLD 的治疗主要基于改变患者的生活方式和药物干预。尽管目前还没有获得 FDA 批准用于治疗 MASLD 的药物，但已有几种潜在的治疗方法已被证明可有效逆转该疾病的组织病理学特征。属于黄酮类的植物成分之一是槲皮素（QE）。QE 具有许多有益的生理作用，包括抗炎、抗癌和抗真菌特性。此外，它还具有天然抗氧化剂的功能。临床前证据表明，QE 可能通过减轻肝损伤和改善代谢健康发挥有益作用。早期人体研究也表明，由于 QE 具有抗氧化、抗炎和调节脂质的特性，因此可能是治疗 MASLD 的有效方法。本文旨在总结 QE 在 MASLD 中的治疗作用的现有信息。
