Department of Surgery, National and Kapodistrian University of Athens, Laikon General Hospital, Athens, Greece.
Department of Gastroenterology, National and Kapodistrian University of Athens, Laikon General Hospital, Athens, Greece.
Saudi J Gastroenterol. 2021 Nov-Dec;27(6):319-330. doi: 10.4103/sjg.sjg_249_21.
Nonalcoholic fatty liver disease (NAFLD) is the most common form of chronic liver disease, affecting almost one-third of the general population and 75% of obese patients with type 2 diabetes. The aim of this article is to review the current evidence concerning the role of quercetin, a natural compound and flavonoid, and its possible therapeutic effects on this modern-day disease. Despite the fact that the exact pathophysiological mechanisms through which quercetin has a hepatoprotective effect on NAFLD are still not fully elucidated, this review clearly demonstrates that this flavonoid has potent antioxidative stress action and inhibitory effects on hepatocyte apoptosis, inflammation, and generation of reactive oxygen species, factors which are linked to the development of the disease. NAFLD is closely associated with increased dietary fat consumption, especially in Western countries. The hepatoprotective effect of quercetin against NAFLD merits serious consideration and further validation by future studies.
非酒精性脂肪性肝病 (NAFLD) 是最常见的慢性肝病，几乎影响了三分之一的普通人群和 75%的 2 型糖尿病肥胖患者。本文旨在综述槲皮素（一种天然化合物和类黄酮）的现有证据及其对这种现代疾病可能的治疗作用。尽管槲皮素对 NAFLD 具有肝保护作用的确切病理生理学机制尚不完全清楚，但本综述清楚地表明，这种类黄酮具有强大的抗氧化应激作用，并能抑制肝细胞凋亡、炎症和活性氧生成，这些因素与疾病的发展有关。NAFLD 与膳食脂肪摄入增加密切相关，尤其是在西方国家。槲皮素对 NAFLD 的肝保护作用值得进一步研究和验证。
