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基于正念减压疗法对学生唾液皮质醇和α-淀粉酶水平、焦虑及抑郁的影响:一项随机平行组临床试验

Effectiveness of Mindfulness-Based Stress Reduction on Salivary Cortisol and α-amylase Level, Anxiety and Depression in Students: A Randomized and Parallel-Group Clinical Trial.

作者信息

Hassanvandi Saba, Mohammadzadegan Reza, Saadat Seyed Hassan, Hatef Boshra, Shahyad Shima

机构信息

Department of Psychology and Counselling, Farhangian University, Rangoon Street, P.O. Box: 14665-889, Tehran, Iran.

Department of Psychology, Khoy Branch, Islamic Azad University, Khoy, Iran.

出版信息

Appl Psychophysiol Biofeedback. 2025 Jul 22. doi: 10.1007/s10484-025-09690-5.

DOI:10.1007/s10484-025-09690-5
PMID:40694304
Abstract

The current trial aimed to assess the effectiveness of Mindfulness-Based Stress Reduction training on salivary cortisol and α-amylase levels, anxiety and depression of students. This research was an experimental trial with a pre-test-post-test design and a control group. The statistical population of the research included all students studying in the universities of Khoy, Iran in 2021. The sample consisted of 30 people who were assigned to two experimental and control groups equally. Stress, anxiety and depression scale (DASS-21), General Health Questionnaire (GHQ-28) and saliva samples were passively taken by ELISA laboratory method with special kits. Data analysis was done using an independent t-test and analysis of covariance using IBM-SPSS version 26 software. The results showed that MBSR training on general health, alpha-amylase level and alpha-amylase/cortisol ratio of experimental group participants was more effective than the control group (P < 0.05). However, it was not effective on students' cortisol levels (P > 0.05). According to the findings, it can be argued that MBSR training has been able to promote the psychological (DASS and general health) and hormonal (alpha amylase level and alpha-amylase/cortisol ratio) mental health indicators of the experimental group participants compared to the control group.

摘要

当前试验旨在评估基于正念减压训练对学生唾液皮质醇和α-淀粉酶水平、焦虑及抑郁状况的有效性。本研究是一项采用前测-后测设计并设有对照组的实验性试验。研究的统计总体包括2021年在伊朗霍伊市各大学就读的所有学生。样本由30人组成,他们被平均分配到实验组和对照组。使用特制试剂盒通过ELISA实验室方法被动采集压力、焦虑和抑郁量表(DASS-21)、一般健康问卷(GHQ-28)及唾液样本。使用IBM-SPSS 26版软件通过独立t检验和协方差分析进行数据分析。结果显示,实验组参与者接受的基于正念减压训练在总体健康、α-淀粉酶水平及α-淀粉酶/皮质醇比值方面比对照组更有效(P < 0.05)。然而,对学生的皮质醇水平无效(P > 0.05)。根据研究结果,可以认为与对照组相比,基于正念减压训练能够提升实验组参与者的心理(DASS和总体健康)及激素(α-淀粉酶水平和α-淀粉酶/皮质醇比值)心理健康指标。

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