Moghadam Mahboobeh Soleymani, Parvizifard Aliakbar, Foroughi Aliakbar, Ahmadi Seyed Mojtaba, Farshchian Negin
Department of Clinical Psychology, Kermanshah University of Medical Sciences, Kermanshah, Iran.
Department of Radiation Oncology, Faculty of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran.
Sci Rep. 2025 Apr 1;15(1):11041. doi: 10.1038/s41598-025-85745-1.
Breast cancer causes numerous physical complications and mental stress that negatively impact patients' performance and quality of life. This study examined the effects of mindfulness-integrated cognitive behavior therapy (MICBT) on depression, anxiety, stress, and sleep quality in women with breast cancer. A clinical trial design with pre-tests and post-tests and a two-month follow-up were used in the current study. The target population was women with breast cancer, 30 of whom were selected through purposeful sampling. Then, 15 participants were placed in the intervention group and 15 in the control group with four random blocks. Those in the intervention group received mindfulness-integrated cognitive behavior therapy, while those in the control group received self-help (an educational book). Demographic questionnaires, the Depression, Anxiety, Stress Scale (DASS-21), and Pittsburgh Sleep Quality Index (PSQI) were used to collect data. Descriptive statistics such as frequency, mean and standard deviation, repeated measures ANOVA, and the Bonferroni test were used to analyze the data. The maximum alpha error level was considered 0.05 to test the hypotheses (p ≥ 0.05). The results showed the effectiveness of MICBT therapy on depression, anxiety, stress, and sleep quality (p < 0.05). The mean scores decreased in all variables, including from 15.47 ± 1.77 in the pre-test to 11.33 ± 4.25 in the post-test for depression, from 13.20 ± 2.60 in the pre-test to 8.67 ± 4.19 in the post-test for anxiety, from 19.73 ± 1.98 in the pre-test to 14.67 ± 2.69 in the post-test for stress and from 9.20 ± 1.74 in the pre-test to 5.07 ± 2.05 in the post-test for sleep quality. Based on the results of this study, it can be concluded that MICBT therapy is effective in reducing depression, anxiety, and stress and improving sleep quality in women with breast cancer. Therefore, it is recommended that affected women use psychological treatments such as MICBT in addition to medical treatments to deal with this stressful and challenging disease. MICBT can improve mood, offer a new cognitive and behavioral system, change patients' habits and thought patterns, and improve their lifestyle.
乳腺癌会引发诸多身体并发症和精神压力，对患者的身体机能和生活质量产生负面影响。本研究探讨了正念整合认知行为疗法（MICBT）对乳腺癌女性患者抑郁、焦虑、压力及睡眠质量的影响。本研究采用了带有前测和后测以及为期两个月随访的临床试验设计。目标人群为乳腺癌女性患者，通过目的抽样选取了30名患者。然后，将15名参与者随机分为4个区组，其中15人被分入干预组，15人被分入对照组。干预组接受正念整合认知行为疗法，而对照组则接受自助干预（一本教育书籍）。使用人口统计学调查问卷、抑郁焦虑压力量表（DASS - 21）和匹兹堡睡眠质量指数（PSQI）来收集数据。采用频率、均值和标准差等描述性统计方法、重复测量方差分析以及邦费罗尼检验来分析数据。检验假设时，最大α错误水平设定为0.05（p≥0.05）。结果显示，MICBT疗法对抑郁、焦虑、压力和睡眠质量有效（p＜0.05）。所有变量的平均得分均有所下降，包括抑郁方面，前测时为15.47±1.77，后测时降至11.33±4.25；焦虑方面，前测时为13.20±2.60，后测时降至8.67±4.19；压力方面，前测时为19.73±1.98，后测时降至14.67±2.69；睡眠质量方面，前测时为9.20±1.74，后测时降至5.07±2.05。基于本研究结果，可以得出结论，MICBT疗法在降低乳腺癌女性患者的抑郁、焦虑和压力以及改善睡眠质量方面是有效的。因此，建议患病女性除了接受药物治疗外，还可采用MICBT等心理治疗方法来应对这种压力大且具有挑战性的疾病。MICBT可以改善情绪，提供新的认知和行为体系，改变患者的习惯和思维模式，并改善其生活方式。
