基于氨基酸的低共熔溶剂作为一种用于绿色合成色烯并嘧啶的通用催化剂。
Amino acid-based deep eutectic solvent as a versatile catalyst for the green synthesis of chromenopyrimidines.
作者信息
Ranjbaran Afagh, Habibi Davood, Monem Arezo, Dehnokhalaji Nastaran
机构信息
Department of Organic Chemistry, Faculty of Chemistry and Petroleum Sciences, Bu-Ali Sina University, Hamedan, Iran.
出版信息
Sci Rep. 2025 Jul 22;15(1):26584. doi: 10.1038/s41598-025-08820-7.
A novel deep eutectic solvent (Thr/Mal-DES) was synthesized by mixing one mole of L-threonine (Thr) with one mole of malonic acid (Mal) and was characterized by FT-IR, H NMR, TGA/DTA, and densitometry techniques. Then, it was used as a highly effective catalyst for the rapid synthesis of chromeno[4,3-d]pyrimidines from the reaction of 4-hydroxy-coumarin, urea/thiourea and aldehyde under solvent-free conditions at 80 °C in high yields and short reaction times.
通过将一摩尔L-苏氨酸（Thr）与一摩尔丙二酸（Mal）混合合成了一种新型的低共熔溶剂（Thr/Mal-DES），并通过傅里叶变换红外光谱（FT-IR）、核磁共振氢谱（H NMR）、热重/差热分析（TGA/DTA）和密度测定技术对其进行了表征。然后，它被用作一种高效催化剂，用于在80℃无溶剂条件下，由4-羟基香豆素、尿素/硫脲和醛反应快速合成色烯并[4,3-d]嘧啶，产率高且反应时间短。
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