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Environmental endocrine disruptors: rethinking the origins of early-onset ER breast cancer.

作者信息

Parrish Meadow, Kuperwasser Charlotte

机构信息

Tufts University School of Medicine, Boston, MA, USA.

出版信息

Nat Rev Cancer. 2025 Jul 22. doi: 10.1038/s41568-025-00854-3.

DOI:10.1038/s41568-025-00854-3
PMID:40696034
Abstract
摘要

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Nat Rev Cancer. 2025 Jul 22. doi: 10.1038/s41568-025-00854-3.
2
Genomic evidence based on eQTL data implicates endocrine disruptors as environmental risk factors for estrogen receptor-positive breast cancer.基于表达数量性状基因座（eQTL）数据的基因组证据表明，内分泌干扰物是雌激素受体阳性乳腺癌的环境风险因素。
Int J Surg. 2025 Aug 1;111(8):5664-5674. doi: 10.1097/JS9.0000000000002642. Epub 2025 Jun 16.
3
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本文引用的文献

1
Trends in Cancer Incidence and Mortality Rates in Early-Onset and Older-Onset Age Groups in the United States, 2010-2019.2010 - 2019年美国早发和晚发年龄组的癌症发病率和死亡率趋势
Cancer Discov. 2025 Jul 3;15(7):1363-1376. doi: 10.1158/2159-8290.CD-24-1678.
2
Geographic differences in early-onset breast cancer incidence trends in the USA, 2001-2020, is it time for a geographic risk score?2001年至2020年美国早发性乳腺癌发病率趋势的地理差异，是时候建立地理风险评分了吗？
Cancer Causes Control. 2025 Feb 12. doi: 10.1007/s10552-025-01968-7.
3
Characterizing Chemical Exposure Trends from NHANES Urinary Biomonitoring Data.
从 NHANES 尿液生物监测数据中描述化学暴露趋势。
Environ Health Perspect. 2024 Jan;132(1):17009. doi: 10.1289/EHP12188. Epub 2024 Jan 29.
4
The mutational landscape of the adult healthy parous and nulliparous human breast.成年有产和无产健康人类乳房的突变景观。
Nat Commun. 2023 Sep 6;14(1):5136. doi: 10.1038/s41467-023-40608-z.
5
Is early-onset cancer an emerging global epidemic? Current evidence and future implications.早发性癌症是一种新兴的全球流行病吗？当前证据和未来影响。
Nat Rev Clin Oncol. 2022 Oct;19(10):656-673. doi: 10.1038/s41571-022-00672-8. Epub 2022 Sep 6.
6
Accelerated aging in normal breast tissue of women with breast cancer.乳腺癌患者正常乳腺组织的加速老化。
Breast Cancer Res. 2021 May 22;23(1):58. doi: 10.1186/s13058-021-01434-7.
7
The Effects of Lifetime Estrogen Exposure on Breast Epigenetic Age.终生雌激素暴露对乳腺表观遗传年龄的影响。
Cancer Epidemiol Biomarkers Prev. 2021 Jun;30(6):1241-1249. doi: 10.1158/1055-9965.EPI-20-1297. Epub 2021 Mar 26.
8
Incidence Trends of Breast Cancer Molecular Subtypes by Age and Race/Ethnicity in the US From 2010 to 2016.2010 年至 2016 年美国按年龄和种族/族裔划分的乳腺癌分子亚型发病趋势。
JAMA Netw Open. 2020 Aug 3;3(8):e2013226. doi: 10.1001/jamanetworkopen.2020.13226.
9
Role of TET Dioxygenases and DNA Hydroxymethylation in Bisphenols-Stimulated Proliferation of Breast Cancer Cells.TET 双加氧酶和 DNA 羟甲基化在双酚类物质刺激乳腺癌细胞增殖中的作用。
Environ Health Perspect. 2020 Feb;128(2):27008. doi: 10.1289/EHP5862. Epub 2020 Feb 27.
10
Immunomodulatory effects of synthetic endocrine disrupting chemicals on the development and functions of human immune cells.合成内分泌干扰化学品对人免疫细胞发育和功能的免疫调节作用。
Environ Int. 2019 Apr;125:350-364. doi: 10.1016/j.envint.2019.01.078. Epub 2019 Feb 8.