Wang Lifu, Yang Chuanle, Gao Zhixiang, Zhang Shaoyun, Zheng Xiaofeng, Liu Lijuan, Xiao Cong
Department of Orthopedics, The Third Hospital of Mianyang·Sichuan Mental Health Center, Mianyang, China.
Department of Nursing, The Third Hospital of Mianyang·Sichuan Mental Health Center, Mianyang, China.
Medicine (Baltimore). 2025 Jul 18;104(29):e43504. doi: 10.1097/MD.0000000000043504.
Giant cell tumors (GCTs) of the distal ulna are rare. Despite their benign nature, these tumors can exhibit local aggressiveness and have the potential to recur after undergoing conventional treatment involving curettage and bone grafting. For aggressive GCTs, radical resection is more suitable. However, these methods have inherent shortcomings, including a high postoperative recurrence rate and poor mechanical stability. Medical applications of the 3D printing technique are on the rise, with orthopedic repair and reconstruction benefiting from the successful implementation of custom-made prostheses created via 3D printing technology.
A 38-year-old male patient presented to a local clinic complaining of a slow-growing painless on over the ulnar aspect of his left wrist for 1 month. The biopsy confirmed the diagnosis of GCTs and was graded as Campanacci grade III.
The diagnosis of GCTs of the distal ulnar was confirmed by biopsy.
The patient received a 2-month preoperative adjuvant chemotherapy with denosumab. Then, a radical distal ulnar resection and hemiarthroplasty are performed using a 3D-printed prosthesis to reconstruct wrist joint function.
During the 2-year follow-up after the surgery, there were no signs of recurrence, and the left wrist function of the patient remained normal.
A well-fitted personalized prosthesis, made using 3D printing techniques, can effectively reconstruct joint function and bone defects resulting from radical distal ulnar resection due to GCTs. This case demonstrates that the combination of radical resection of a GCT in the distal ulna and reconstruction with a 3D printed personalized prosthesis could lead to successful oncologic and functional outcomes.
尺骨远端骨巨细胞瘤（GCT）较为罕见。尽管这些肿瘤本质上是良性的，但它们可能表现出局部侵袭性，并且在接受包括刮除术和骨移植的传统治疗后有复发的可能。对于侵袭性GCT，根治性切除更为合适。然而，这些方法存在固有缺点，包括术后复发率高和机械稳定性差。3D打印技术在医学领域的应用正在增加，骨科修复和重建受益于通过3D打印技术成功制造的定制假体。
一名38岁男性患者到当地诊所就诊，主诉左腕尺侧无痛性肿物缓慢生长1个月。活检确诊为GCT，分级为Campanacci III级。
活检确诊为尺骨远端GCT。
患者接受了为期2个月的术前地诺单抗辅助化疗。然后，使用3D打印假体进行尺骨远端根治性切除和半关节成形术，以重建腕关节功能。
术后2年随访期间，无复发迹象，患者左腕功能保持正常。
采用3D打印技术制作的贴合良好的个性化假体，可有效重建因GCT导致的尺骨远端根治性切除后的关节功能和骨缺损。该病例表明，尺骨远端GCT根治性切除与3D打印个性化假体重建相结合可取得成功的肿瘤学和功能学结果。
