Shi Naiwen, Zhang Ruixin, Yao Shankun, Sun Qian, Wu Yanping, Yang Xiuzhi, Yang Ying, Tan Yehong, Zhang Jingwen, Chen Yuncong, Guo Zijian
State Key Laboratory of Coordination Chemistry, School of Chemistry and Chemical Engineering, Chemistry and Biomedicine Innovation Center (ChemBIC), ChemBioMed Interdisciplinary Research Center, Nanjing University, Nanjing 210023, China.
State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing 210023, China.
J Mater Chem B. 2025 Aug 13;13(32):9883-9892. doi: 10.1039/d5tb01221j.
Photothermal therapy (PTT) is emerging as a promising alternative therapy for tumor ablation through spatiotemporally controlled hyperthermia. However, designing near-infrared photothermal agents with a high photothermal conversion efficiency (PCE) and high photostability remains considerably challenging. To address this limitation, we engineered optimal molecule 3TPA by employing CF-BODIPY as an electron-deficient core and incorporating three electron-donating triphenylamine rotors, which showed an extended absorption wavelength and improved PCE. To optimize the therapeutic performance, 3TPA was further encapsulated into a DSPE-mPEG-based amphiphilic polymer to form 3TPA NPs, which exhibited high PCE ( = 57.2%) and remarkable photostability. studies revealed that 3TPA NPs selectively accumulated in tumor sites under NIR-I/NIR-II fluorescence imaging guidance, simultaneously enabling effective photo-mediated tumor ablation through a precision PTT effect. This work not only presents a robust NIR-II therapeutic agent but also opens up more possibilities for its application in photothermal therapy in the field of biomedicine.
光热疗法（PTT）正作为一种有前景的替代疗法出现，可通过时空控制的热疗实现肿瘤消融。然而，设计具有高光热转换效率（PCE）和高光稳定性的近红外光热剂仍然极具挑战性。为解决这一局限性，我们通过采用CF-硼二吡咯作为缺电子核心并引入三个供电子三苯胺转子来设计优化分子3TPA，其显示出扩展的吸收波长和提高的PCE。为优化治疗性能，3TPA进一步被封装到基于DSPE-甲氧基聚乙二醇的两亲聚合物中以形成3TPA纳米颗粒，其表现出高PCE（ = 57.2%）和显著的光稳定性。研究表明，3TPA纳米颗粒在近红外I/近红外II荧光成像引导下选择性地在肿瘤部位积聚，同时通过精确的光热疗法效应实现有效的光介导肿瘤消融。这项工作不仅展示了一种强大的近红外II治疗剂，还为其在生物医学领域的光热疗法中的应用开辟了更多可能性。
