Meshkinpour H, Harmon D, Thompson R, Yu J
Paraplegia. 1985 Oct;23(5):272-6. doi: 10.1038/sc.1985.44.
The resting colonic motor activity before and consecutively after spinal cord transection was recorded in male Sprague-Dawley rats. Recording probes were anchored surgically in the ascending and descending colon. Pressure changes were recorded on a dynograph using a low compliance perfusion system. A motility index took into account the amplitude, duration and frequency of contractions. Following a baseline recording animals were subjected either to spinal cord transection at T4 level or a sham operation. The recording sessions continued regularly on alternate days for the observation period of 3 weeks. Transection of the thoracic spinal cord markedly reduced the motility index of the distal colon on the first postoperative day. However, the motor activity gradually returned to pre-operative values after 7 days. Sham surgery did not influence the motor activity. These findings suggest that colonic motor activity is influenced by spinal shock and probably by different neural mechanisms mediating proximal and distal activities of the colon in rats.
在雄性Sprague-Dawley大鼠中记录脊髓横断前后及连续的静息结肠运动活性。记录探头通过手术固定在升结肠和降结肠。使用低顺应性灌注系统在记录仪上记录压力变化。运动指数考虑了收缩的幅度、持续时间和频率。在进行基线记录后，动物接受T4水平的脊髓横断或假手术。在3周的观察期内，记录 sessions 每隔一天定期继续。胸段脊髓横断在术后第一天显著降低了远端结肠的运动指数。然而，7天后运动活性逐渐恢复到术前值。假手术不影响运动活性。这些发现表明结肠运动活性受脊髓休克影响，可能还受介导大鼠结肠近端和远端活动的不同神经机制影响。
