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Lactylation in cancer: Unveiling new layers of complexity.

作者信息

Zhang Shanghang, Xie Bingteng, Zhu Xin, Dong Suwei, Li Mo

机构信息

State Key Laboratory of Multimedia Information Processing, School of Computer Science, Peking University, Beijing 100191, China.

Key Laboratory of Molecular Medicine and Biological Diagnosis and Treatment (Ministry of Industry and Information Technology), School of Life Science, Beijing Institute of Technology, Beijing 100081, China.

出版信息

Innovation (Camb). 2025 Apr 22;6(7):100914. doi: 10.1016/j.xinn.2025.100914. eCollection 2025 Jul 7.

DOI:10.1016/j.xinn.2025.100914
PMID:40697784
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12277713/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8a1f/12277713/13ee323f285f/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8a1f/12277713/13ee323f285f/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8a1f/12277713/13ee323f285f/gr1.jpg

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1
Lactylation in cancer: Unveiling new layers of complexity.癌症中的乳酰化：揭示新的复杂层面。
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Sirtuin 3-mediated delactylation of malic enzyme 2 disrupts redox balance and inhibits colorectal cancer growth.沉默调节蛋白3介导的苹果酸酶2去乳酸化破坏氧化还原平衡并抑制结直肠癌生长。
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Lactylation and its roles in diseases: a systematic bibliometric exploration of the research landscape.乳酰化及其在疾病中的作用：对研究现状的系统文献计量学探索
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本文引用的文献

1
Recent advances of lysine lactylation in prokaryotes and eukaryotes.赖氨酸乳酰化在原核生物和真核生物中的最新进展。
Front Mol Biosci. 2025 Jan 9;11:1510975. doi: 10.3389/fmolb.2024.1510975. eCollection 2024.
2
Integrated Lactylome Characterization Reveals the Molecular Dynamics of Protein Regulation in Gastrointestinal Cancers.整合乳酰组学分析揭示了胃肠道癌症中蛋白质调控的分子动态。
Adv Sci (Weinh). 2024 Sep;11(35):e2400227. doi: 10.1002/advs.202400227. Epub 2024 Jul 17.
3
NBS1 lactylation is required for efficient DNA repair and chemotherapy resistance.
高效的DNA修复和化疗耐药性需要NBS1乳酸化。
Nature. 2024 Jul;631(8021):663-669. doi: 10.1038/s41586-024-07620-9. Epub 2024 Jul 3.
4
KAT8-catalyzed lactylation promotes eEF1A2-mediated protein synthesis and colorectal carcinogenesis.KAT8 催化的乳酰化促进 eEF1A2 介导的蛋白质合成和结直肠肿瘤发生。
Proc Natl Acad Sci U S A. 2024 Feb 20;121(8):e2314128121. doi: 10.1073/pnas.2314128121. Epub 2024 Feb 15.
5
Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.乳酰化组分析提示肝细胞癌中存在依赖乳酰化的代谢适应机制。
Nat Metab. 2023 Jan;5(1):61-79. doi: 10.1038/s42255-022-00710-w. Epub 2023 Jan 2.