Wang Dandan, Rong Hao, Ma Ke, Peng Jun
Department of Thoracic Surgery, Sichuan Clinical Research Center for Cancer, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, University of Electronic Science and Technology of China, Chengdu, Sichuan, China.
Front Immunol. 2025 Jun 16;16:1609596. doi: 10.3389/fimmu.2025.1609596. eCollection 2025.
Lactate, a central product of glucose metabolism, plays a vital role in energy supply and signal transduction, and it also participates in gene transcription regulation through lactylation. Metabolic reprogramming is a key feature of tumor cells and highlights the important role of lactylation in cancer development. Recent studies have emphasized the significant regulatory roles of lactylation in cancer, suggesting that it may serve as a potential target for treatment. This review discusses the mechanisms, regulation, and functions of lactylation in cancer. It also explores the possible significance of lactylation as a marker for the diagnosis and therapy of tumor, and evaluates the therapeutic prospects of targeting lactylation. While the precise mechanisms of lactylation in cancer regulation require further investigation, its significant influence indicates promising avenues for future research.
乳酸是葡萄糖代谢的核心产物，在能量供应和信号转导中发挥着至关重要的作用，并且它还通过乳酰化参与基因转录调控。代谢重编程是肿瘤细胞的一个关键特征，凸显了乳酰化在癌症发展中的重要作用。最近的研究强调了乳酰化在癌症中的重要调节作用，表明它可能成为一个潜在的治疗靶点。这篇综述讨论了乳酰化在癌症中的机制、调控和功能。它还探讨了乳酰化作为肿瘤诊断和治疗标志物的可能意义，并评估了靶向乳酰化的治疗前景。虽然乳酰化在癌症调控中的精确机制需要进一步研究，但其显著影响为未来研究指明了有前景的方向。
