Department of Dermatology, Huashan Hospital, Fudan University, Shanghai Institute of Dermatology, Shanghai, PR China.
Department of Transfusion Medicine, Huashan Hospital, Fudan University, Shanghai, China.
J Dermatolog Treat. 2024 Dec;35(1):2377665. doi: 10.1080/09546634.2024.2377665. Epub 2024 Jul 28.
Numerous studies have linked the inflammatory pathway in psoriasis and metabolic disease, while no specific marker defined it. It is worth exploring the association of β2-microglobulin (β2M) in psoriasis severity and comorbidities.
To investigate the correlation between blood β2M level and psoriasis severity, to explore the inflammatory factors influencing the occurrence of psoriasis comorbidities such as arthritis, diabetes, and hypertension.
Ninety-seven psoriasis patients were analyzed in the cohort retrospective study during 12 weeks.
Significantly higher levels of blood β2M and ESR were observed in the group that patients' PASI ≥10 than in the group that PASI <10. Blood β2M level had strong significantly positive correlations with the PASI in Pearson's correlation analysis. In the model that systemic inflammatory factors to find psoriasis comorbidity risk factors, logistic regression analysis showed that blood β2M level was the significant risk factor associated with diabetes and hypertension. High-sensitivity C-reactive protein (hsCRP) was the significant risk factor associated with arthritis.
Patients with a severer psoriasis tended to have higher blood β2M levels and severer inflammatory state. In the systemic inflammation indexes, the level of blood β2M affected the risk of hypertension and diabetes, and hsCRP affected the risk of arthritis in patients with psoriasis.
许多研究将银屑病的炎症途径与代谢疾病联系起来，而没有明确的特定标志物。探索β2-微球蛋白（β2M）在银屑病严重程度和合并症中的相关性是值得的。
研究血液β2M 水平与银屑病严重程度的相关性，探讨影响关节炎、糖尿病和高血压等银屑病合并症发生的炎症因素。
对 97 例银屑病患者进行了为期 12 周的队列回顾性研究。
PASI≥10 的患者组的血β2M 和 ESR 水平明显高于 PASI＜10 的患者组。Pearson 相关分析显示，血β2M 水平与 PASI 呈强显著正相关。在寻找银屑病合并症风险因素的系统炎症因子模型中，logistic 回归分析显示，血β2M 水平是与糖尿病和高血压相关的显著危险因素。高敏 C 反应蛋白（hsCRP）是与关节炎相关的显著危险因素。
银屑病严重程度较高的患者往往具有更高的血β2M 水平和更严重的炎症状态。在系统炎症指标中，血β2M 水平影响高血压和糖尿病的风险，hsCRP 影响银屑病患者关节炎的风险。
