Mirescu Andrada-Elena, Deleanu Dan George, Baltă George, Tofolean Ioana Teodora, Baltă Florian, Cristescu Irina-Elena, Jurja Sanda
"Ovidius" University of Constanţa, Constanţa, Romania.
"Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania.
Rom J Ophthalmol. 2025 Apr-Jun;69(2):235-242. doi: 10.22336/rjo.2025.37.
Our objective was to assess retinal microcirculation and photoreceptor parameters in both healthy individuals and patients with vascular retinal diseases using adaptive optics ophthalmoscopy. This technology enhances optical system resolution to 2 µm by correcting wavefront aberrations, revolutionizing in vivo studies of ocular structures.
Our study examined the clinical applications of adaptive optics in both healthy individuals and patients with vascular retinal diseases, including nonproliferative diabetic retinopathy, proliferative diabetic retinopathy, and macular telangiectasia (MacTel) type 2.
In our study, we observed a higher wall-to-lumen ratio (WLR) value in our patient with proliferative diabetic retinopathy compared to our healthy volunteer. Additionally, we found a positive correlation between WLR and the severity of diabetic retinopathy. Furthermore, cone density was lower in all quadrants of our patient with proliferative diabetic retinopathy. For our patient diagnosed with MacTel type 2, the cone mosaic appeared irregular and blurred, with notable cone loss, especially on the temporal side of the macula, consistent with the typical location of MacTel type 2 lesions.
Adaptive optics imaging assesses retinal changes in vascular diseases despite acquisition challenges. The obtained images aid in tracking the progression of diabetic retinopathy and detecting early changes of MacTel Type 2. Our study highlights both vascular and photoreceptor changes, quantifying these parameters to enhance the understanding of these vascular diseases.
Adaptive optics imaging is an advanced technique that provides high-resolution visualization of the microstructure of retinal vasculature and photoreceptors. This technology enhances our understanding of both healthy and vascular retinal conditions, aiding in diagnosis, monitoring, and prognosis.
我们的目的是使用自适应光学检眼镜评估健康个体和视网膜血管疾病患者的视网膜微循环和光感受器参数。该技术通过校正波前像差将光学系统分辨率提高到2微米，彻底改变了眼部结构的体内研究。
我们的研究考察了自适应光学在健康个体和视网膜血管疾病患者中的临床应用，这些疾病包括非增殖性糖尿病视网膜病变、增殖性糖尿病视网膜病变和2型黄斑毛细血管扩张症（MacTel）。
在我们的研究中，我们观察到增殖性糖尿病视网膜病变患者的壁腔比（WLR）值高于健康志愿者。此外，我们发现WLR与糖尿病视网膜病变的严重程度呈正相关。此外，增殖性糖尿病视网膜病变患者所有象限的视锥细胞密度均较低。对于我们诊断为2型MacTel的患者，视锥细胞镶嵌显得不规则且模糊，有明显的视锥细胞丢失，尤其是在黄斑颞侧，这与2型MacTel病变的典型位置一致。
尽管存在采集挑战，但自适应光学成像可评估血管疾病中的视网膜变化。所获得的图像有助于追踪糖尿病视网膜病变的进展并检测2型MacTel的早期变化。我们的研究突出了血管和光感受器的变化，对这些参数进行量化以增强对这些血管疾病的理解。
自适应光学成像是一种先进技术，可提供视网膜血管系统和光感受器微观结构的高分辨率可视化。该技术增强了我们对健康和视网膜血管状况的理解，有助于诊断、监测和预后。
