Gyabaah Solomon, Blay Samuel Nguah, Asibey Shadrack Osei, Ovbiagele Bruce, Sarfo Fred Stephen
Komfo Anokye Teaching Hospital Kumasi Ghana.
Kwame Nkrumah University of Science and Technology Kumasi Ghana.
Health Sci Rep. 2025 Jul 22;8(7):e71100. doi: 10.1002/hsr2.71100. eCollection 2025 Jul.
Cognitive decline is one of the most deleterious consequences of hypertension. Hypertension is rife in sub-Saharan Africa, where control of blood pressure is abysmally poor.
This study is aimed at assessing the determinants of cognitive performance among Ghanaian hypertensive patients.
This was a cross-sectional study conducted at a single district hospital among hypertensives aged ≥ 18 years. Global cognitive performance is assessed using the Montreal Cognitive Assessment (MOCA). A multivariable linear regression analysis was performed, and a beta coefficient was computed to identify factors independently associated with the MOCA score.
We enrolled 214 adults living with hypertension; the mean (SD) age was 64 (13.4) years, and 168 (78.5%) were females. Factors, with their adjusted beta coefficients (95% CI), independently associated with cognitive performance were age, -0.10 (-0.16, -0.04), < 0.001; female sex, -2.3 (-4.2, -0.35), = 0.021, secondary and tertiary-level educational attainment +5.2 (3.5, 6.9), < 0.001 and +4.1 (0.49, 7.7), = 0.026 respectively. In sensitivity unadjusted analyses, body mass index (BMI), with a beta coefficient of +0.18(0.08, 0.29), < 0.001, was associated with MOCA score in females. Among the male participants, a history of heart failure, -11 (-15, -5.9), < 0.001, history of stroke -11 (-15, -5.9), < 0.001, BMI -0.31 (-0.49, -0.13), = 0.002 and uncontrolled hypertension -3.5 (-6.9, -0.15), = 0.047 were associated with MOCA score.
Increasing age and female sex are associated with poorer global cognitive performance, while higher educational attainment is associated with good global cognitive performance among Ghanaians living with hypertension.
认知功能衰退是高血压最有害的后果之一。高血压在撒哈拉以南非洲地区十分普遍，该地区的血压控制情况非常糟糕。
本研究旨在评估加纳高血压患者认知表现的决定因素。
这是一项在一家地区医院对年龄≥18岁的高血压患者进行的横断面研究。使用蒙特利尔认知评估量表（MOCA）评估整体认知表现。进行多变量线性回归分析，并计算β系数以确定与MOCA评分独立相关的因素。
我们纳入了214名成年高血压患者；平均（标准差）年龄为64（13.4）岁，其中168名（78.5%）为女性。与认知表现独立相关的因素及其调整后的β系数（95%置信区间）分别为：年龄，-0.10（-0.16，-0.04），P<0.001；女性，-2.3（-4.2，-0.35），P=0.021；接受过中等和高等教育，分别为+5.2（3.5，6.9），P<0.001和+4.1（0.49，7.7），P=0.026。在未调整的敏感性分析中，体重指数（BMI）的β系数为+0.18（0.08，0.29），P<0.001，与女性的MOCA评分相关。在男性参与者中，心力衰竭病史，-11（-15，-5.9），P<0.001；中风病史，-11（-15，-5.9），P<0.001；BMI，-0.31（-0.49，-0.13），P=0.002；以及未控制的高血压，-3.5（-6.9，-0.15），P=0.047，均与MOCA评分相关。
年龄增长和女性与较差的整体认知表现相关，而较高的教育程度与加纳高血压患者良好的整体认知表现相关。
