Morales-González Maria, Díaz Luis Eduardo, Dominguez-Paz Carlos, Valero Manuel F
Doctoral Program in Engineering, Faculty of Engineering, Universidad de La Sabana, Chía 140013, Colombia.
Energy, Materials and Environmental Group, GEMA, Faculty of Engineering, Universidad de La Sabana, Chía 140013, Colombia.
Polymers (Basel). 2022 Jul 24;14(15):2990. doi: 10.3390/polym14152990.
Dressings made with polyurethanes have been found to exhibit good and varied biological properties that make them good candidates for this application. However, as has been seen, the wound-healing process is complex, which includes four different stages. So far, the design and evaluation of polyurethane for wound dressing has focused on achieving good properties (mechanical, physicochemical, and biological), but each of them separates from the others or even directed at only one of the stages of skin wound-healing. Therefore, the aim of this systematic review is to explore the applications of polyurethanes in wound dressings and to determine whether could be designed to cover more than one stage of skin wound-healing. The PRISMA guidelines were followed. The current research in this field does not consider each stage separately, and the design of polyurethane dressings is focused on covering all the stages of wound healing with a single material but is necessary to replace polyurethanes in short periods of time. Additionally, little emphasis is placed on the hemostasis stage and further characterization of polyurethanes is still needed to correlate mechanical and physicochemical properties with biological properties at each stage of the wound-healing. Current research demonstrates an effort to characterize the materials physiochemically and mechanically, but in terms of their biological properties, most of the literature is based on the performance of histological tests of explants morphologically probing the compromised tissues, which give an indication of the potential use of polyurethanes in the generation of wound-healing dressings.
已发现由聚氨酯制成的敷料具有良好且多样的生物学特性，这使其成为该应用的理想候选材料。然而，如前所述，伤口愈合过程很复杂，包括四个不同阶段。到目前为止，用于伤口敷料的聚氨酯的设计和评估主要集中在实现良好的性能（机械性能、物理化学性能和生物学性能），但它们各自相互分离，甚至仅针对皮肤伤口愈合的一个阶段。因此，本系统综述的目的是探索聚氨酯在伤口敷料中的应用，并确定是否可以设计出能覆盖皮肤伤口愈合多个阶段的聚氨酯。本研究遵循PRISMA指南。该领域目前的研究并未分别考虑每个阶段，聚氨酯敷料的设计侧重于用单一材料覆盖伤口愈合的所有阶段，但在短时间内需要更换聚氨酯。此外，对止血阶段的关注较少，仍需要对聚氨酯进行进一步表征，以将机械性能和物理化学性能与伤口愈合各阶段的生物学性能相关联。目前的研究表明，人们努力对材料进行物理化学和机械表征，但就其生物学性能而言，大多数文献基于对外植体进行形态学组织学测试的结果，这些测试对外植体受损组织进行形态学探测，从而表明聚氨酯在伤口愈合敷料生成中的潜在用途。
