Vromans H, De Boer A H, Bolhuis G K, Lerk C F, Kussendrager K D, Bosch H
Pharm Weekbl Sci. 1985 Oct 25;7(5):186-93. doi: 10.1007/BF02307575.
Lactose is available in several crystalline forms, which differ in binding properties. A new method of estimating the fragmentation propensity was applied to investigate the consolidation and compaction behaviour of this excipient for direct compression. Mercury porosimetry was used to demonstrate that crystalline lactose fragments during compaction. Tablet strength was found to be dependent on the degree of fragmentation only. This finding indicates that the nature of the actual binding must be the same for the different types of crystalline lactose.
乳糖有几种晶型，它们在结合特性上有所不同。一种估算破碎倾向的新方法被应用于研究这种用于直接压片的辅料的固结和压实行为。压汞法被用于证明结晶乳糖在压实过程中会破碎。发现片剂强度仅取决于破碎程度。这一发现表明，不同类型的结晶乳糖的实际结合性质必定相同。
