McKenna A, McCafferty D F
J Pharm Pharmacol. 1982 Jun;34(6):347-51. doi: 10.1111/j.2042-7158.1982.tb04727.x.
The effect of particle size variation on tablet tensile strength for spray-dried lactose, Sta-Rx 1500 and Avicel PH-101 was investigated. Decreasing the particle size of spray-dried lactose and Sta-Rx 1500 resulted in stronger compacts whereas the tablet tensile strength of Avicel PH-101 was unaffected by particle size variation. The Heckel relationship, at two different contact times, was used to examine the predominant compaction mechanism. This was independent of the size fractions studied for all three materials. Angle of repose and Hausner ratio measurements indicated a correlation between the internal forces of friction and cohesion of the sized powders and the tensile strength of compacts formed from them.
研究了喷雾干燥乳糖、Sta-Rx 1500和微晶纤维素PH-101的粒度变化对片剂抗张强度的影响。减小喷雾干燥乳糖和Sta-Rx 1500的粒度会使压坯更强，而微晶纤维素PH-101的片剂抗张强度不受粒度变化的影响。使用在两个不同接触时间的赫克尔关系来研究主要的压实机制。这与所有三种材料所研究的粒度级分无关。休止角和豪斯纳比测量表明，分级粉末的内摩擦力和内聚力与由它们形成的压坯的抗张强度之间存在相关性。
