Yuan Lanlai, Cui Feipeng, Yin Ge, Shi Mengwen, Aximu Nadida, Tian Yaohua, Sun Yu
Department of Otolaryngology Head and Neck Surgery, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu 610072, China.
Department of Otorhinolaryngology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.
Audiol Res. 2025 Jul 16;15(4):88. doi: 10.3390/audiolres15040088.
: Observational studies have shown that chronic obstructive pulmonary disease (COPD) is associated with an increased risk of hearing impairment. However, causality remains unclear, including with respect to lung function. This study aimed to investigate the associations of lung function and COPD with hearing impairment in the UK Biobank and confirm potential causalities using Mendelian randomization (MR). Cross-sectional analyses were performed using logistic regression models in a subsample of the UK Biobank. Two-sample MR analyses were performed on summary statistics for forced expiratory volume in one second (FEV1), forced vital capacity (FVC), COPD, and sensorineural hearing loss. : FEV1 and FVC were negatively associated with hearing impairment, with odds ratios (95% confidence intervals) of 0.80 (0.77, 0.84) and 0.80 (0.76, 0.83), respectively. COPD was positively associated with hearing impairment, with an odds ratio (95% confidence interval) of 1.10 (1.02, 1.18). In the MR analyses, a negative association was found between FVC and sensorineural hearing loss, with an odds ratio (95% confidence interval) of 0.91 (0.83, 0.99). For FVE1 and COPD, no significant associations were found. : The results of this study showed that FVC was causally associated with hearing impairment, suggesting a potential protective effect of FVC on hearing impairment.
观察性研究表明，慢性阻塞性肺疾病（COPD）与听力障碍风险增加有关。然而，因果关系仍不明确，包括与肺功能的关系。本研究旨在调查英国生物银行中肺功能和COPD与听力障碍的关联，并使用孟德尔随机化（MR）确认潜在的因果关系。在英国生物银行的一个子样本中，使用逻辑回归模型进行横断面分析。对一秒用力呼气量（FEV1）、用力肺活量（FVC）、COPD和感音神经性听力损失的汇总统计数据进行两样本MR分析。FEV1和FVC与听力障碍呈负相关，优势比（95%置信区间）分别为0.80（0.77，0.84）和0.80（0.76，0.83）。COPD与听力障碍呈正相关，优势比（95%置信区间）为1.10（1.02，1.18）。在MR分析中，发现FVC与感音神经性听力损失之间存在负相关，优势比（95%置信区间）为0.91（0.83，0.99）。对于FEV1和COPD，未发现显著关联。本研究结果表明，FVC与听力障碍存在因果关系，提示FVC对听力障碍可能具有保护作用。
