Kim Sean Hyungwoo, Min Hua, Xue Hong, Kitsantas Panagiota
Department of Biopharmaceutics and Pharmacogenomics, Bernard J. Dunn School of Pharmacy, Shenandoah University, 1775 N. Sector Court, Winchester, VA 22601, USA.
Department of Health Administration and Policy, College of Public Health, George Mason University, 4400 University Drive, Fairfax, VA 22030, USA.
Pharmacy (Basel). 2025 Jul 2;13(4):92. doi: 10.3390/pharmacy13040092.
Polysubstance use (PSU) involving marijuana among women of reproductive age (WRA) is linked to psychosocial harm, yet research on the combined effects of marijuana with stimulants, opioids, tobacco, and binge drinking remains limited. The purpose of this study was to assess the prevalence of PSU in WRA with past month MJ use and examine the association between PSU status and social sequelae, including getting in trouble with the law, relationship difficulty with others, and lower achievement in job or educational settings, in this group of women. We used data from the United States 2015-2019 National Survey on Drug Use and Health, which included 11,895 non-institutionalized WRA (18-44 years old) with reported use of MJ in the past month. Descriptive statistics, chi-squared tests, and multivariable logistic regression analyses were conducted to describe the sample and assess associations between PSU and social sequelae. Nearly 4.5% of the women who used MJ in the past month had experienced social sequelae regardless of PSU status. Women who used three or more substances along with MJ had the highest adjusted odds (AOR = 3.18, 95% CI 1.90, 5.31) of social sequelae relative to monosubstance MJ users. Concurrent use of multiple substances significantly increased the likelihood of social sequelae among women MJ users.
育龄期女性（WRA）中涉及大麻的多物质使用（PSU）与心理社会伤害有关，但关于大麻与兴奋剂、阿片类药物、烟草和暴饮联合使用的综合影响的研究仍然有限。本研究的目的是评估过去一个月使用过大麻的育龄期女性中多物质使用的患病率，并检查该组女性中多物质使用状况与社会后遗症之间的关联，包括触犯法律、与他人关系困难以及在工作或教育环境中成就较低。我们使用了美国2015 - 2019年全国药物使用和健康调查的数据，其中包括11,895名过去一个月报告使用过大麻的非机构化育龄期女性（18 - 44岁）。进行了描述性统计、卡方检验和多变量逻辑回归分析，以描述样本并评估多物质使用与社会后遗症之间的关联。在过去一个月使用过大麻的女性中，近4.5%的人无论多物质使用状况如何都经历过社会后遗症。与单一物质大麻使用者相比，同时使用三种或更多物质和大麻的女性出现社会后遗症的调整后优势比最高（AOR = 3.18，95% CI 1.90，5.31）。多种物质同时使用显著增加了大麻使用者女性出现社会后遗症的可能性。
