种痘样水疱病患者细胞中紫外线诱导的非预定DNA合成异常低下。
Abnormally low UV-induced unscheduled DNA synthesis in cells from a patient with hydroa vacciniforme.
作者信息
Andrews A D, Halasz C L, Poh-Fitzpatrick M B
出版信息
Photodermatol. 1985 Oct;2(5):315-8.
PMID:4070030
Abstract
Skin fibroblasts from a patient with the photosensitive disorder hydroa vacciniforme were tested in vitro for DNA repair capacity. The rate of ultraviolet light (254 nm)-induced unscheduled DNA synthesis (UDS) in these fibroblasts was found to be 51-59% of the rate found in 4 normal fibroblasts strains. The patient had none of the clinical signs of the classic DNA deficient disease, xeroderma pigmentosum.
摘要
对一名患有光敏性疾病种痘样水疱病患者的皮肤成纤维细胞进行了体外DNA修复能力测试。发现这些成纤维细胞中紫外线（254nm）诱导的非预定DNA合成（UDS）速率为4种正常成纤维细胞株中所发现速率的51 - 59%。该患者没有典型的DNA缺陷疾病——着色性干皮病的任何临床症状。
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