Dóda M, György L
Pol J Pharmacol Pharm. 1985 May-Jun;37(3):397-404.
The influence of dopaminergic agonists on the spontaneous and evoked activity of the sympathetic postganglionic renal efferent fibres was studied in lightly anaesthetized cats (urethane, 600 mg/kg, ip). Apomorphine, bromocriptine and piribedil (0.2, 0.07 and 0.4 mg/kg iv, respectively) depressed the spontaneous activity of the renal nerve. Electrical stimulation (16 V, 0.3 ms, 2-128 Hz, 2 s) of the sciatic nerve elicited a burst of activity of the sympathetic efferents followed by a silent period. Apomorphine and piribedil (the same doses as above) prolonged the duration of the silent periods. All these effects of dopaminergic agonists were antagonized by haloperidol (0.05-0.1 mg/kg iv). The results suggest that administration of dopaminergic agonists leads to preponderance of inhibition in the somato-sympathetic reflex integration.
在轻度麻醉的猫（腹腔注射600mg/kg乌拉坦）身上，研究了多巴胺能激动剂对交感神经节后肾传出纤维的自发活动和诱发活动的影响。阿扑吗啡、溴隐亭和吡贝地尔（分别静脉注射0.2、0.07和0.4mg/kg）抑制了肾神经的自发活动。坐骨神经电刺激（16V，0.3ms，2 - 128Hz，2s）可引发交感传出纤维的一阵活动，随后是一个静息期。阿扑吗啡和吡贝地尔（与上述相同剂量）延长了静息期的持续时间。多巴胺能激动剂的所有这些作用均被氟哌啶醇（静脉注射0.05 - 0.1mg/kg）拮抗。结果表明，给予多巴胺能激动剂会导致躯体 - 交感反射整合中抑制作用占优势。
