Xu Jing, Sandler Dale P
Beijing Center for Disease Prevention and Control, Beijing 100013, China.
Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC, USA.
J Hazard Mater. 2025 Sep 15;496:139311. doi: 10.1016/j.jhazmat.2025.139311. Epub 2025 Jul 19.
Hypertension affects nearly a billion people globally, but the association between airborne phthalates and hypertension remains unclear.
We conducted a cross-sectional analysis of 47,465 women from the Sister Study. Exposure to airborne bis (2-ethylhexyl) phthalate (DEHP), dibutyl phthalate (DBP), and dimethyl phthalate (DMP) was estimated using the US Environmental Protection Agency's 2005 National Air Toxics Assessment database linked to participants' addresses. Hypertension was defined as systolic blood pressure ≥ 140 mm Hg, or diastolic blood pressure ≥ 90 mm Hg, or use of antihypertensive medications. Prevalence ratios (PRs) and 95 % confidence intervals (CIs) were calculated using multivariable log-binomial regression. We further used quantile-based g-computation to assess the joint effect and conducted analyses stratified by race/ethnicity.
DEHP (PR =1.06, 95 % CI: 1.02-1.09, P trend=0.001), DBP (PR =1.04, 95 % CI: 1.00-1.07, P trend=0.02), and DMP (PR =1.03, 95 % CI: 1.00-1.06, P trend=0.8) were associated with increased hypertension risk. Associations of DEHP and DMP were stronger in women of other races/ethnicities compared to non-Hispanic White participants. A one quartile increase in the phthalate mixture was associated with a 2 % increase in hypertension prevalence (PR=1.02, 95 % CI:1.00-1.03, P = 0.02).
Airborne phthalate exposures were associated with higher hypertension prevalence, especially among women other than non-Hispanic White.
高血压在全球影响着近十亿人，但空气中邻苯二甲酸盐与高血压之间的关联仍不明确。
我们对“姐妹研究”中的47465名女性进行了横断面分析。利用与参与者住址相关联的美国环境保护局2005年国家空气毒物评估数据库估算空气中邻苯二甲酸二（2-乙基己基）酯（DEHP）、邻苯二甲酸二丁酯（DBP）和邻苯二甲酸二甲酯（DMP）的暴露情况。高血压定义为收缩压≥140毫米汞柱，或舒张压≥90毫米汞柱，或使用抗高血压药物。采用多变量对数二项回归计算患病率比（PRs）和95%置信区间（CIs）。我们进一步使用基于分位数的g计算来评估联合效应，并按种族/民族进行分层分析。
DEHP（PR = 1.06，95%CI：1.02 - 1.09，P趋势 = 0.001）、DBP（PR = 1.04，95%CI：1.00 - 1.07，P趋势 = 0.02）和DMP（PR = 1.03，95%CI：1.00 - 1.06，P趋势 = 0.8）与高血压风险增加相关。与非西班牙裔白人参与者相比，DEHP和DMP在其他种族/民族女性中的关联更强。邻苯二甲酸酯混合物增加一个四分位数与高血压患病率增加2%相关（PR = 1.02，95%CI：1.00 - 1.03，P = 0.02）。
空气中邻苯二甲酸盐暴露与较高的高血压患病率相关，尤其是在非西班牙裔白人以外的女性中。
