CICS-UBI - Health Sciences Research Centre, University of Beira Interior, 6200-506 Covilhã, Portugal.
CICS-UBI - Health Sciences Research Centre, University of Beira Interior, 6200-506 Covilhã, Portugal; FCS-UBI - Faculty of Health Sciences, University of Beira Interior, 6200-506 Covilhã, Portugal.
J Hazard Mater. 2023 Sep 5;457:131680. doi: 10.1016/j.jhazmat.2023.131680. Epub 2023 May 23.
Being an essential component in the plastics industry, phthalates are ubiquitous in the environment and in everyday life. They are considered environmental contaminants that have been classified as endocrine-disrupting compounds. Despite di-2-ethylhexyl phthalate (DEHP) being the most common plasticizer and the most studied to date, there are many others that, in addition to being widely used in the plastic, are also applied in the medical and pharmaceutical industries and cosmetics. Due to their wide use, phthalates are easily absorbed by the human body where they can disrupt the endocrine system by binding to molecular targets and interfering with hormonal homeostasis. Thus, phthalates exposure has been implicated in the development of several diseases in different age groups. Collecting information from the most recent available literature, this review aims to relate human phthalates' exposure with the development of cardiovascular diseases throughout all ages. Overall, most of the studies presented demonstrated an association between phthalates and several cardiovascular diseases, either from prenatal or postnatal exposure, affecting foetuses, infants, children, young and older adults. However, the mechanisms underlying these effects remain poorly explored. Thus, considering the cardiovascular diseases incidence worldwide and the constant human exposure to phthalates, this topic should be extensively studied to understand the mechanisms involved.
作为塑料工业的重要组成部分，邻苯二甲酸酯在环境和日常生活中无处不在。它们被认为是环境污染物，已被归类为内分泌干扰化合物。尽管邻苯二甲酸二（2-乙基己基）酯（DEHP）是最常见的增塑剂，也是迄今为止研究最多的增塑剂，但还有许多其他增塑剂不仅广泛用于塑料，还应用于医药和制药行业以及化妆品。由于它们的广泛使用，邻苯二甲酸酯很容易被人体吸收，在体内它们可以通过与分子靶标结合并干扰激素平衡来破坏内分泌系统。因此，邻苯二甲酸酯暴露与不同年龄组的几种疾病的发展有关。本综述从最新的可用文献中收集信息，旨在将人类邻苯二甲酸酯暴露与各年龄段心血管疾病的发展联系起来。总的来说，大多数研究表明，邻苯二甲酸酯与几种心血管疾病之间存在关联，无论是产前还是产后暴露，都会影响胎儿、婴儿、儿童、青少年和老年人。然而，这些影响的机制仍未得到充分探索。因此，考虑到全球心血管疾病的发病率和人类对邻苯二甲酸酯的持续暴露，应该广泛研究这个课题，以了解所涉及的机制。
