光诱导的鸟类眼球增大：II. 持续黑暗

Photoinduced buphthalmic avian eyes: II. Continuous darkness.

作者信息

Whitley R D, Albert R A, Brewer R N, McDaniel G R, Pidgeon G L, Mora E C

出版信息

Poult Sci. 1985 Oct;64(10):1869-74. doi: 10.3382/ps.0641869.

Abstract

Chickens raised from 2 to 14 weeks of age in continuous darkness (OL:24D) developed shallow anterior chambers and buphthalmos (megaloglobus). Chickens raised in continuous darkness developed ocular changes similar to that reported in chickens raised in continuous fluorescent and incandescent light and in dim light. Corneal diameters and axial globe lengths were an inconsistent means of documenting ocular enlargement. Iridocorneal angles were narrowed on scanning electron microscopy (SEM). Intraocular pressure (IOP) was not different from control chickens. The chicken is proposed as a model to study ocular development, the effects of lid suture on infants, axial myopia, preglaucomatous changes, and possibly pharmacologic effects of antiglaucoma preparations.

摘要

在持续黑暗环境（光照周期：24小时黑暗）中饲养2至14周龄的鸡，会出现前房变浅和眼球增大（牛眼）的情况。在持续黑暗中饲养的鸡出现的眼部变化，与在持续荧光灯、白炽灯及昏暗光线下饲养的鸡所报告的变化相似。角膜直径和眼轴长度并不是记录眼球增大的可靠指标。扫描电子显微镜（SEM）显示虹膜角膜角变窄。眼压与对照鸡无异。鸡被提议作为研究眼部发育、眼睑缝合对婴儿的影响、轴性近视、青光眼前期变化以及抗青光眼制剂可能的药理作用的模型。