Huang Xinru, Wu Hao, Wu Xiao, Su Weiwei, Li Peibo
Guangdong Engineering and Technology Research Center for Quality and Efficacy Re Evaluation of Post-Marketed TCM, Guangdong Provincial Key Laboratory of Plant Stress Biology, State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-sen University, Guangzhou 510275, PR China.
Guangdong Engineering and Technology Research Center for Quality and Efficacy Re Evaluation of Post-Marketed TCM, Guangdong Provincial Key Laboratory of Plant Stress Biology, State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-sen University, Guangzhou 510275, PR China.
Pharmacol Res. 2025 Sep;219:107871. doi: 10.1016/j.phrs.2025.107871. Epub 2025 Jul 21.
The intestinal microflora represents a collection of microorganisms residing in the gastrointestinal tract. Alterations in the composition of the intestinal microflora may disrupt the stability of the intestinal ecosystem and adversely affect the health of the host. Previously, growing studies have demonstrated that dietary interventions have the potential to reshape the intestinal microflora and thereby promote host health. Naringenin and naringin are natural dietary flavonoids, which possess a wide range of biological activities, including anti-inflammatory, antioxidant, anticancer, hypoglycemic activities, and the ability to improve lipid metabolism. Studies indicate that the intestinal microflora can metabolize naringenin and naringin into several phenolic and aromatic ring-fission catabolites, and consequently exerting unique physiological activities. In turn, naringenin and naringin were found to impact on the composition and metabolites of intestinal microflora. This review will summarize existing studies on naringenin/naringin therapeutic effects and the role of intestinal microflora in them, and discuss their potential to improve host health as natural agents.
肠道微生物群是指存在于胃肠道中的微生物集合。肠道微生物群组成的改变可能会破坏肠道生态系统的稳定性，并对宿主健康产生不利影响。此前，越来越多的研究表明，饮食干预有潜力重塑肠道微生物群，从而促进宿主健康。柚皮素和柚皮苷是天然膳食黄酮类化合物，具有广泛的生物活性，包括抗炎、抗氧化、抗癌、降血糖活性以及改善脂质代谢的能力。研究表明，肠道微生物群可将柚皮素和柚皮苷代谢为几种酚类和芳香环裂变分解代谢物，从而发挥独特的生理活性。反过来，人们发现柚皮素和柚皮苷会影响肠道微生物群的组成和代谢产物。本综述将总结关于柚皮素/柚皮苷治疗作用以及肠道微生物群在其中的作用的现有研究，并讨论它们作为天然物质改善宿主健康的潜力。
