Sun Shumei, Tong Zhilan, Yuan Zhagen, Chen Hanli, Zhu Xiaoying, Hong Xiaoyan, Yao Gengxin, Zhong Min
Department of Anesthesiology, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou, 510120, China.
Eye (Lond). 2025 Jul 23. doi: 10.1038/s41433-025-03930-y.
In vitro and in vivo studies suggested that magnesium might have preventive effects on cataracts; however, the epidemiological evidence is limited. The objective of this study was to examine the association between magnesium intake and the odds of experiencing cataract surgery.
A total of 8185 individuals aged ≥30 years were extracted from the National Health and Nutritional Examination Surveys (NHANES) in the cycles from 2003 to 2008. Magnesium intake was assessed using the 24-hour dietary recall method. The questionnaire determined whether participants had cataract surgery or not. Multivariable logistic regressions were performed to explore the associations between magnesium intake and the risk of cataract surgery.
The overall prevalence of cataracts was 13.4% (1094/8185). After controlling for potential confounders, we observed a significant inverse association between magnesium intake and cataracts, both as a continuous variable [odds ratio (OR): 0.78, 95% confidence interval (CI): 0.65-0.96, p = 0.013] and quartiles with the highest quartile compared to the lowest (OR: 0.78, 95% CI: 0.61-0.98, p trend = 0.027).
These results suggest that higher magnesium intake appears to be helpful for cataract prevention; however, additional prospective studies are required to ascertain whether magnesium intake can lead to a decrease in cataracts.
体外和体内研究表明，镁可能对白内障具有预防作用；然而，流行病学证据有限。本研究的目的是检验镁摄入量与接受白内障手术几率之间的关联。
从2003年至2008年各轮次的美国国家健康与营养检查调查（NHANES）中提取了总共8185名年龄≥30岁的个体。使用24小时饮食回忆法评估镁摄入量。问卷确定参与者是否接受过白内障手术。进行多变量逻辑回归以探讨镁摄入量与白内障手术风险之间的关联。
白内障的总体患病率为13.4%（1094/8185）。在控制潜在混杂因素后，我们观察到镁摄入量与白内障之间存在显著的负相关，无论是作为连续变量[比值比（OR）：0.78，95%置信区间（CI）：0.65 - 0.96，p = 0.013]，还是与最低四分位数相比的最高四分位数（OR：0.78，95% CI：0.61 - 0.98，p趋势 = 0.027）。
这些结果表明，较高的镁摄入量似乎有助于预防白内障；然而，需要更多的前瞻性研究来确定镁摄入量是否会导致白内障发病率降低。
