Musculoskeletal Research Laboratory and Centre of Musculoskeletal Aging and Regeneration, Department of Orthopaedics and Traumatology, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong SAR, China.
The Sir Yue-Kong Pao Cancer Centre, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong SAR, China.
Theranostics. 2024 Jun 24;14(10):3963-3983. doi: 10.7150/thno.96959. eCollection 2024.
Piezo1, a mechanosensitive ion channel, has emerged as a key player in translating mechanical stimuli into biological signaling. Its involvement extends beyond physiological and pathological processes such as lymphatic vessel development, axon growth, vascular development, immunoregulation, and blood pressure regulation. The musculoskeletal system, responsible for structural support, movement, and homeostasis, has recently attracted attention regarding the significance of Piezo1. This review aims to provide a comprehensive summary of the current research on Piezo1 in the musculoskeletal system, highlighting its impact on bone formation, myogenesis, chondrogenesis, intervertebral disc homeostasis, tendon matrix cross-linking, and physical activity. Additionally, we explore the potential of targeting Piezo1 as a therapeutic approach for musculoskeletal disorders, including osteoporosis, muscle atrophy, intervertebral disc degeneration, and osteoarthritis.
Piezo1 是一种机械敏感的离子通道，已成为将机械刺激转化为生物信号的关键分子。其作用不仅涉及到生理和病理过程，如淋巴管发育、轴突生长、血管发育、免疫调节和血压调节等，还包括骨骼肌肉系统的结构支撑、运动和内稳态维持等方面。骨骼肌肉系统中的 Piezo1 最近受到了广泛关注。本文旨在全面总结 Piezo1 在骨骼肌肉系统中的研究进展，重点探讨其在骨形成、成肌分化、软骨形成、椎间盘内稳态、肌腱基质交联和体力活动等方面的作用。此外，我们还探讨了靶向 Piezo1 作为治疗骨骼肌肉疾病（包括骨质疏松症、肌肉萎缩、椎间盘退行性变和骨关节炎）的潜在治疗方法。
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