Ajith Namratha A, Bhavasar Rashmi, Bhavasar Rahul, Srivastava Himanshu, Qureshi Sameera M R, Mempally Hari K
Department of Oral Pathology and Microbiology, KM Shah Dental College and Hospital, Sumandeep Vidyapeeth Deemed to be University, Vadodara, Gujarat, India.
Department of Pharmacology, Jawahar Medical Foundation's A.C.P.M Medical College, Dhule, Maharashtra, India.
J Oral Maxillofac Pathol. 2025 Apr-Jun;29(2):222-227. doi: 10.4103/jomfp.jomfp_106_24. Epub 2025 Jun 30.
Covid patients experience changes in overall health and very less is known about variation in oral manifestations as per severity of Covid and how far it differs, which needs evaluation.
To analyse COVID-19 hospitalized patients for variations in clinical, demographic details, and oral manifestations as per severity of involvement (mild, moderate, and severe).
This prospective study had 12 participants of RT-PCR positive COVID in each group, and hence, 36 participants were selected for mild, moderate, and severe cases. All patients' data were noted from the first day of hospitalization until completion of treatment, with a follow-up of a minimum of 7 days.
In our study, the M: F ratio was 5:4 with a mean age of 39.44 years. The most common oral sites involved were labial mucosa, followed by buccal mucosa. In all mild, moderate, and severe cases, there was a significant association of labial mucosa ( = 0.038) and buccal mucosa ( = 0.011). COVID participants had sublingual varicosity, burning sensation, aphthous ulcers, mucositis, angular chelitis, coated tongue, candidiasis, dryness of the oral cavity, herpes labialis, geographic and fissured tongue.
Results show that oral manifestations and the well-being of patients worsen from mild to severe cases of COVID-19, poor oral hygiene, and multiple drug therapy for illness contribute to the same. These findings have significant implications for understanding oral manifestations as per variation in severity of COVID-19, with a multidisciplinary approach for management of COVID-19.
新冠患者的整体健康状况会发生变化,而关于新冠严重程度不同时口腔表现的差异以及差异程度,我们所知甚少,这需要进行评估。
分析新冠住院患者根据受累严重程度(轻度、中度和重度)在临床、人口统计学细节和口腔表现方面的差异。
这项前瞻性研究每组有12名RT-PCR检测呈阳性的新冠患者,因此共选取了36名患者,分别为轻度、中度和重度病例。记录了所有患者从住院第一天到治疗结束的数据,随访时间至少为7天。
在我们的研究中,男女比例为5:4,平均年龄为39.44岁。最常受累的口腔部位是唇黏膜,其次是颊黏膜。在所有轻度、中度和重度病例中,唇黏膜(P = 0.038)和颊黏膜(P = 0.011)均存在显著关联。新冠患者有舌下静脉曲张、烧灼感、阿弗他溃疡、黏膜炎、口角炎、舌苔、念珠菌病、口腔干燥、唇疱疹、地图舌和沟纹舌。
结果表明,新冠患者从轻度到重度病例,口腔表现和健康状况会恶化,口腔卫生差以及疾病的多种药物治疗对此有影响。这些发现对于理解新冠严重程度不同时的口腔表现具有重要意义,有助于采用多学科方法管理新冠患者。