Blanchard D C, Takushi R, Blanchard R J, Flannelly K J, Kemble E D
Physiol Behav. 1985 Sep;35(3):349-53. doi: 10.1016/0031-9384(85)90307-5.
Recent studies indicate that fluprazine hydrochloride reduces offensive attack in laboratory rats and mice without decreasing defensive behavior during conspecific encounters. Since wild rats and rats displaying the "septal lesion syndrome" show much more pronounced defensive reactions than do normal laboratory rats, these animals were used to provide a more critical test of fluprazine's effectiveness on defense. When a dose of fluprazine hydrochloride (8 mg/kg), previously shown to be highly effective in reducing or eliminating offense, was given to wild and septal syndrome rats these animals showed no reliable decrement in a wide range of defensive reactions including biting attack (defensive attack) to human handling and other stimulation. These findings support the view that fluprazine does not appreciably affect defensive attack or other defensive behaviors even though it strongly inhibits offensive attack.
近期研究表明，盐酸氟奋乃静可减少实验大鼠和小鼠的攻击性攻击行为，同时在同种个体相遇时不会降低其防御行为。由于野生大鼠和表现出“隔区损伤综合征”的大鼠比正常实验大鼠表现出更明显的防御反应，因此这些动物被用于对氟奋乃静对防御的有效性进行更严格的测试。当给野生大鼠和患有隔区综合征的大鼠注射先前已证明在减少或消除攻击性方面非常有效的剂量的盐酸氟奋乃静（8毫克/千克）时，这些动物在包括对人类处理和其他刺激的咬击攻击（防御性攻击）在内的广泛防御反应中并未表现出可靠的下降。这些发现支持了这样一种观点，即氟奋乃静即使强烈抑制攻击性攻击，也不会明显影响防御性攻击或其他防御行为。
