Ma Jixuan, Yao Yuxin, Xie Yujia, Yin Haoyu, Yang Shiyu, Shang Bingxin, You Xiaojie, Guo Yanjun, Chen Weihong
Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, and State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China.
Department of Occupational & Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China.
Environ Health (Wash). 2025 Apr 28;3(7):787-794. doi: 10.1021/envhealth.4c00198. eCollection 2025 Jul 18.
We aim to assess the modification effects of omega-3 polyunsaturated fatty acid (PUFA) levels on relationships between long-term air pollutants exposure and chronic obstructive pulmonary disease (COPD) risk. A total of 82,706 nonsmokers were finally included in the UK Biobank. The concentrations of circulating omega-3 PUFA (including total omega-3 and docosahexaenoic acid [DHA]) were measured by using a targeted high-throughput nuclear magnetic resonance metabolomics platform. Land-use regression models were used to estimate concentrations of nitrogen dioxide (NO) and particulate matter (PM and PM) for each individual. Additionally, systemic inflammation levels were assessed using the low-grade inflammation score (INFLA-score) to elucidate the potential mechanism. We noted that the observed effects could be modified by circulating omega-3 PUFA levels (-interaction < 0.05). Specifically, the significant pollutants-COPD associations were mainly observed in the lower circulating omega-3 PUFA groups. In contrast, there was no statistical evidence for increased COPD risk associated with air pollutants in subjects with higher circulating omega-3 PUFA. Mediation analysis further indicated that circulating omega-3 PUFA modified the air pollution-associated COPD risk might partly by reducing systemic inflammation. In summary, circulating omega-3 PUFA may provide protection against the COPD risk caused by long-term exposure to air pollutants.
我们旨在评估ω-3多不饱和脂肪酸（PUFA）水平对长期暴露于空气污染物与慢性阻塞性肺疾病（COPD）风险之间关系的修饰作用。英国生物银行最终纳入了82706名不吸烟者。使用靶向高通量核磁共振代谢组学平台测量循环ω-3 PUFA（包括总ω-3和二十二碳六烯酸 [DHA]）的浓度。土地利用回归模型用于估计每个个体的二氧化氮（NO）和颗粒物（PM和PM）浓度。此外，使用低度炎症评分（INFLA评分）评估全身炎症水平以阐明潜在机制。我们注意到观察到的效应可能会受到循环ω-3 PUFA水平的修饰（交互作用P<0.05）。具体而言，显著的污染物-COPD关联主要在循环ω-3 PUFA水平较低的组中观察到。相比之下，在循环ω-3 PUFA水平较高的受试者中，没有统计学证据表明与空气污染物相关的COPD风险增加。中介分析进一步表明，循环ω-3 PUFA改变空气污染相关的COPD风险可能部分是通过减轻全身炎症。总之，循环ω-3 PUFA可能对长期暴露于空气污染物导致的COPD风险提供保护。
