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被忽视的诊断:一例老年患者自主神经功能障碍与慢性头晕伴神经影像学关联的病例报告

The Overlooked Diagnosis: A Case Report on Autonomic Dysfunction and Chronic Dizziness in an Elderly Patient With Neuroimaging Correlation.

作者信息

Ak Saran, Kumar Tribhuwan, Zabihullah Md, Banodhe Gagan K, Mannan Raihan

机构信息

Physiology, All India Institute of Medical Sciences, Patna, Patna, IND.

出版信息

Cureus. 2025 Jun 23;17(6):e86590. doi: 10.7759/cureus.86590. eCollection 2025 Jun.

Abstract

Dizziness is a common yet diagnostically challenging complaint in the elderly, often resulting from multifactorial causes such as vestibular dysfunction, autonomic impairment, and cerebrovascular disease. This case report describes a 74-year-old woman with persistent, non-vertiginous dizziness, exacerbated by postural changes, but without orthostatic hypotension or classic vestibular signs. Comprehensive evaluation, including autonomic function tests, tilt-table testing, and neuroimaging, revealed autonomic dysfunction and chronic small-vessel ischemic changes in the periventricular white matter, along with a small hypodense lesion in the pons. Specifically, the patient exhibited reduced heart rate variability, impaired parasympathetic reflexes, and cerebrovascular alterations suggestive of disrupted autonomic pathways. This case underscores the importance of integrating autonomic testing with neuroimaging to elucidate the underlying pathophysiology of chronic dizziness in elderly patients.

摘要

头晕是老年人常见但诊断具有挑战性的症状,通常由多因素引起,如前庭功能障碍、自主神经功能损害和脑血管疾病。本病例报告描述了一名74岁女性,患有持续性、非眩晕性头晕,体位改变会加重,但无直立性低血压或典型前庭体征。全面评估,包括自主神经功能测试、倾斜试验和神经影像学检查,发现自主神经功能障碍、脑室周围白质慢性小血管缺血性改变,以及脑桥有一个小的低密度病变。具体而言,患者表现出心率变异性降低、副交感神经反射受损以及提示自主神经通路中断的脑血管改变。该病例强调了将自主神经测试与神经影像学相结合以阐明老年患者慢性头晕潜在病理生理机制的重要性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4a81/12285608/17f61eaf864f/cureus-0017-00000086590-i01.jpg

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