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:一种用于细菌细胞生物学和发病机制的模型。

: a model for bacterial cell biology and pathogenesis.

作者信息

Pinho Mariana G, Götz Friedrich, Peschel Andreas

机构信息

Instituto de Tecnologia Química e Biológica António Xavier, Universidade NOVA de Lisboa, Oeiras, Portugal.

Microbial Genetics, Interfaculty Institute of Microbiology and Infection Medicine Tübingen (IMIT), University of Tübingen, Tübingen, Germany.

出版信息

J Bacteriol. 2025 Aug 21;207(8):e0010625. doi: 10.1128/jb.00106-25. Epub 2025 Jul 24.

Abstract

has emerged as an important model organism in bacterial cell biology and pathogenesis due to its clinical relevance, genetic versatility, and adaptability. This review explores how has contributed to advances in the fields of bacterial cell wall synthesis and cell division, particularly due to its minimal cell wall synthesis machinery and simple spherical shape. has also been fundamental in antimicrobial resistance studies, particularly due to the increasing threat of antibiotic-resistant strains. Furthermore, ' dual lifestyle as both a commensal and a pathogen has provided key insights into host-microbe interactions, biofilm formation, and immune evasion strategies. This review underscores the importance of continued research on as a basis for the development of novel antimicrobial strategies and vaccine approaches.

摘要

由于其临床相关性、遗传多样性和适应性,已成为细菌细胞生物学和发病机制中的重要模式生物。本综述探讨了其如何推动细菌细胞壁合成和细胞分裂领域的进展,特别是因其最小的细胞壁合成机制和简单的球形形状。在抗微生物耐药性研究中也具有重要意义,尤其是由于耐抗生素菌株构成的日益增长的威胁。此外,作为共生菌和病原体的双重生活方式为宿主-微生物相互作用、生物膜形成和免疫逃避策略提供了关键见解。本综述强调了持续研究其作为开发新型抗菌策略和疫苗方法基础的重要性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1051/12369386/630ca1597f4d/jb.00106-25.f001.jpg

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