Pathogen Molecular Genetics Section, Laboratory of Bacteriology, National Institute of Allergy and Infectious Diseases, US National Institutes of Health, Bethesda, MD, USA.
Pathogen Molecular Genetics Section, Laboratory of Bacteriology, National Institute of Allergy and Infectious Diseases, US National Institutes of Health, Bethesda, MD, USA.
Lancet Microbe. 2024 Jun;5(6):e606-e618. doi: 10.1016/S2666-5247(24)00040-5. Epub 2024 Mar 19.
Staphylococcus aureus is a leading cause of death by infectious diseases worldwide. Treatment of S aureus infections is difficult due to widespread antibiotic resistance, necessitating alternative approaches and measures for prevention of infection. Because S aureus infections commonly arise from asymptomatic colonisation, decolonisation is considered a key approach for their prevention. Current decolonisation procedures include antibiotic-based and antiseptic-based eradication of S aureus from the nose and skin. However, despite the widespread implementation and partial success of such measures, S aureus infection rates remain worrisome, and resistance to decolonisation agents is on the rise. In this Review we outline the epidemiology and mechanisms of S aureus colonisation, describe how colonisation underlies infection, and discuss current and novel approaches for S aureus decolonisation, with a focus on the latest findings on probiotic strategies and the intestinal S aureus colonisation site.
金黄色葡萄球菌是全球由传染病导致死亡的主要原因。由于广泛存在抗生素耐药性，金黄色葡萄球菌感染的治疗变得困难，因此需要替代方法和预防感染的措施。由于金黄色葡萄球菌感染通常源自无症状定植，去定植被认为是预防感染的关键方法。目前的去定植程序包括使用抗生素和抗菌剂从鼻腔和皮肤中消除金黄色葡萄球菌。然而，尽管这些措施得到了广泛实施并取得了部分成功，但金黄色葡萄球菌感染率仍然令人担忧，并且对去定植剂的耐药性也在上升。在这篇综述中，我们概述了金黄色葡萄球菌定植的流行病学和机制，描述了定植如何导致感染，并讨论了目前和新的金黄色葡萄球菌去定植方法，重点介绍了益生菌策略和肠道金黄色葡萄球菌定植部位的最新发现。
