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Avocado Oil Prevents Neurological and Behavioral Alterations in a Quinolinic Acid-Induced Model of Huntington's Disease.

作者信息

González-Guevara Edith, Martínez-Gopar Pablo Eliasib, Sánchez-Mendoza Alicia, Angeles-López Quetzalli Denisse, López-Orozco Diego, Tristán-López Luis, El-Hafidi Mohammed, Becerril-Cavazos Mitzi Daniela, Peña-Segura Claudia, Silva-Islas Carlos Alfredo, Pérez-Severiano Francisca

机构信息

Laboratorio de Neurofarmacología Molecular y Nanotecnología, Instituto Nacional de Neurología y Neurocirugía Manuel Velasco Suárez, Avenida Insurgentes Sur No. 3877, Colonia La Fama. Alcaldía Tlalpan, Mexico City, CP 14269, Mexico.

Departamento de Sistemas Biológicos, Universidad Autónoma Metropilitana, Unidad Xochimilco, Mexico, Mexico.

出版信息

Neurochem Res. 2025 Jul 24;50(4):249. doi: 10.1007/s11064-025-04496-7.

DOI:10.1007/s11064-025-04496-7
PMID:40705210
Abstract
摘要

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1
Avocado Oil Prevents Neurological and Behavioral Alterations in a Quinolinic Acid-Induced Model of Huntington's Disease.鳄梨油可预防喹啉酸诱导的亨廷顿舞蹈病模型中的神经和行为改变。
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Suppressing inflammatory cascade by cyclo-oxygenase inhibitors attenuates quinolinic acid induced Huntington's disease-like alterations in rats.环氧化酶抑制剂抑制炎症级联反应可减轻喹啉酸诱导的大鼠类似亨廷顿病的改变。
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Essential fatty acid-rich diets protect against striatal oxidative damage induced by quinolinic acid in rats.富含必需脂肪酸的饮食可预防喹啉酸诱导的大鼠纹状体氧化损伤。
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Bilateral quinolinic acid-induced lipid peroxidation, decreased striatal monoamine levels and neurobehavioral deficits are ameliorated by GIP receptor agonist D-AlaGIP in rat model of Huntington's disease.双侧喹啉酸诱导的脂质过氧化、纹状体单胺水平降低和神经行为缺陷可被 GIP 受体激动剂 D-AlaGIP 改善，在亨廷顿病大鼠模型中。
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Coniferaldehyde reverses 3-nitropropionic acid-induced Huntington's disease pathologies via PKM2 restoration and JAK2/STAT3 inhibition.松柏醛通过恢复PKM2和抑制JAK2/STAT3逆转3-硝基丙酸诱导的亨廷顿舞蹈病病理变化。
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本文引用的文献

1
Mast cells and histamine are involved in the neuronal damage observed in a quinolinic acid-induced model of Huntington's disease.肥大细胞和组织胺参与了在喹啉酸诱导的亨廷顿病模型中观察到的神经元损伤。
J Neurochem. 2022 Jan;160(2):256-270. doi: 10.1111/jnc.15527. Epub 2021 Oct 31.
2
Avocado oil: Production and market demand, bioactive components, implications in health, and tendencies and potential uses.鳄梨油：生产与市场需求、生物活性成分、对健康的影响，以及趋势和潜在用途。
Compr Rev Food Sci Food Saf. 2021 Jul;20(4):4120-4158. doi: 10.1111/1541-4337.12784. Epub 2021 Jun 19.
3
Neuroprotective effects of oleic acid in rodent models of cerebral ischaemia.
油酸在脑缺血啮齿动物模型中的神经保护作用。
Sci Rep. 2019 Jul 24;9(1):10732. doi: 10.1038/s41598-019-47057-z.
4
Avocado Oil: Characteristics, Properties, and Applications.鳄梨油：特性、性质与应用。
Molecules. 2019 Jun 10;24(11):2172. doi: 10.3390/molecules24112172.
5
Rich fatty acids diet of fish and olive oils modifies membrane properties in striatal rat synaptosomes.富含脂肪酸的鱼类和橄榄油饮食可改变纹状体大鼠突触小体的膜特性。
Nutr Neurosci. 2021 Jan;24(1):1-12. doi: 10.1080/1028415X.2019.1584692. Epub 2019 Mar 1.
6
Sustained Activation of JNK Induced by Quinolinic Acid Alters the BDNF/TrkB Axis in the Rat Striatum.喹啉酸诱导的 JNK 持续激活改变大鼠纹状体中的 BDNF/TrkB 轴。
Neuroscience. 2018 Jul 15;383:22-32. doi: 10.1016/j.neuroscience.2018.04.034. Epub 2018 May 3.
7
Hepatic Dysfunction Caused by Consumption of a High-Fat Diet.高脂肪饮食导致的肝功能障碍。
Cell Rep. 2017 Dec 12;21(11):3317-3328. doi: 10.1016/j.celrep.2017.11.059.
8
Effect of an avocado oil-enhanced diet (Persea americana) on sucrose-induced insulin resistance in Wistar rats.鳄梨油增强饮食（Persea americana）对 Wistar 大鼠蔗糖诱导的胰岛素抵抗的影响。
J Food Drug Anal. 2016 Apr;24(2):350-357. doi: 10.1016/j.jfda.2015.11.005. Epub 2016 Jan 11.
9
Integrated molecular landscape of Parkinson's disease.帕金森病的综合分子图谱
NPJ Parkinsons Dis. 2017 Apr 10;3:14. doi: 10.1038/s41531-017-0015-3. eCollection 2017.
10
Essential fatty acid-rich diets protect against striatal oxidative damage induced by quinolinic acid in rats.富含必需脂肪酸的饮食可预防喹啉酸诱导的大鼠纹状体氧化损伤。
Nutr Neurosci. 2017 Sep;20(7):388-395. doi: 10.1080/1028415X.2016.1147683. Epub 2016 Feb 29.