Arnetz B B, Fjellner B, Eneroth P, Kallner A
Psychosom Med. 1985 Nov-Dec;47(6):528-41. doi: 10.1097/00006842-198511000-00003.
Psychoendocrine and metabolic reactions during standardized stressor exposure (color-word conflict test and forced mental arithmetics) were studied in ten psoriatic and ten matched healthy subjects. During resting conditions, the groups were similar with regard to psychologic and biochemical variables, except for plasma glucose, which was slightly elevated in the psoriatic group. During stressor exposure, the psoriatic group reported significantly higher strain levels. Blood pressure, pulse rate, plasma glucose, and urinary adrenaline excretion increased in both groups during exposure, with more pronounced increases of the latter two in the psoriatic group. Serum cortisol, prolactin, progesterone and urinary cortisol decreased in both groups during stressor exposure. The decrease in serum cortisol was more pronounced in the psoriatic group. Thus, no psychoendocrine differences were found between the healthy and psoriatic subjects during resting conditions. In contrast, during a standardized stressor exposure, psoriatic subjects reported higher levels of strain, which was accompanied by higher levels of urinary adrenaline and lower levels of plasma cortisol. These results fit the hypothesis that psoriatic patients perceive certain challenging situations as more stressful than do nonpsoriatic controls, and react accordingly in their differential psychoendocrine reaction pattern. Possible pathophysiologic implications of the different pituitary-adrenocortical and sympatho-adrenomedullary reactions in psoriatics submitted to stressor exposure are discussed.
在十名银屑病患者和十名匹配的健康受试者中，研究了标准化应激源暴露（颜色-单词冲突测试和强制心算）期间的心理内分泌和代谢反应。在静息状态下，两组在心理和生化变量方面相似，但银屑病组的血浆葡萄糖略有升高。在应激源暴露期间，银屑病组报告的应激水平明显更高。暴露期间两组的血压、脉搏率、血浆葡萄糖和尿肾上腺素排泄均增加，后两者在银屑病组中增加更为明显。应激源暴露期间两组的血清皮质醇、催乳素、孕酮和尿皮质醇均降低。银屑病组血清皮质醇的降低更为明显。因此，在静息状态下，健康受试者和银屑病患者之间未发现心理内分泌差异。相比之下，在标准化应激源暴露期间，银屑病患者报告的应激水平更高，同时伴有尿肾上腺素水平升高和血浆皮质醇水平降低。这些结果符合以下假设：银屑病患者将某些具有挑战性的情况视为比非银屑病对照组更具压力，并在其不同的心理内分泌反应模式中做出相应反应。讨论了银屑病患者在应激源暴露下不同的垂体-肾上腺皮质和交感-肾上腺髓质反应可能的病理生理意义。
