2008 - 2023年中国牛支原体新型氟喹诺酮耐药突变的出现
Emergence of Novel Fluoroquinolone Resistance Mutations in Mycoplasma bovis, China, 2008-2023.
作者信息
Lan Shimei, Liu Shuang, Cui Wenjing, Li Zhangcheng, Hao Huafang, Baz Ahmed Adel, Liang Jinjia, Jin Xiangrui, Yan Xinmin, Gao Pengcheng, Zheng Fuying, Chen Shengli, Chu Yuefeng
出版信息
Emerg Infect Dis. 2025 Aug;31(8):1676-1679. doi: 10.3201/eid3108.241137.
Abstract
We investigated quinolone resistance in Mycoplasma bovis samples isolated in China during 2008-2023. Sequence type 52 was the dominant genotype; GyrA (S83F/Y) and ParC (S80R) protein double mutations caused high resistance to fluoroquinolones. Increased vigilance and surveillance of M. bovis infections in cattle will be needed to prevent disease.
摘要
我们调查了2008年至2023年期间在中国分离的牛支原体样本中的喹诺酮耐药性。序列类型52是主要基因型；GyrA（S83F/Y）和ParC（S80R）蛋白双突变导致对氟喹诺酮类药物高度耐药。需要提高对牛支原体感染的警惕性并加强监测，以预防疾病。
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